Further reduction of DA clearance in the striatum after repeated METH binge in Nurr-1 +/− mice.

<p>Extracellular DA concentration was measured using chronoamperometry after local application of low doses (10.2+/−0.6 pmole/site) of DA through micropipettes in mouse striatum after saline, 1xMETH or 2XMETH treatment. Amplitude of DA signals was normalized by comparison to the log of dose used. Extracellular DA concentration was significantly enhanced in Nurr1 +/−, compared to +/+ mice, after 2XMETH treatment (*, p<0.05, Two-way ANOVA, post hoc Newman-Keuls test).