Increased bone erosion in NT3.catK mice during serum transfer arthritis.

<p><b>A</b>. Hindpaw thickness was measured bilaterally every day following serum injection on day 0 and 2. n = 8 Ctl; n = 12 NT3.catK. <b>B</b>. Serum was collected on day 0 and 7 and used for CTX assay to measure OC activity. n = 5 per group. <b>C–E</b>. Mice were sacrificed on day 7, and hind legs were fixed and scanned with microCT. (C) BMD of the distal femur and proximal tibia, including both cortical and trabecular bone. n = 5 per group. 3D reconstructions of knee joints (D) and paws (E) from both front and side views are displayed. * <i>p<0.05</i>; ** <i>p<0.01</i> versus controls.