Decreased type 1 IFN and enhanced MHV-68 loads in lungs of TLR2- and MyD88-deficient mice.

<p>(<b>A and B</b>) WT, TLR2−/− and MyD88−/− mice (3 mice/group) were mock infected or infected in. with MHV-68 (10⁵ PFU/mouse). Lung homogenates were prepared 24 hours post-infection for IFN-α (<b>A</b>) and IFN-β (<b>B</b>) determination by ELISA. (<b>C and D</b>) WT, TLR2−/− and MyD88−/− mice (5 mice/group) were infected in. with MHV-68 (10⁵ PFU/mouse). Lung homogenates were prepared on days 3 and 5 post-infection for determination of viral load (<b>C</b>) and lung IL-6 concentration (<b>D</b>). Graphs are representative of three different experiments. Values significantly different (<i>p</i><0.05) from WT mice are indicated (*).