A strong negative correlation is observed between peripheral mononuclear cell proliferation and AHL lipophilicity.

<p>The IC₅₀ for human peripheral mononuclear cell proliferation (PBMCs) isolated from three donors (* denotes n = 2) in the presence of AHLs of chain lengths between 8 and 14 carbons (values obtained from <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0013522#pone.0013522-Chhabra1" target="_blank">[18]</a>) exhibit a strong negative correlation (Pearsons r = −0.895, <i>p</i> = 0.016) against the predicted octanol/water partition coefficient (LogP) for each compound (calculated using ACD/i-Lab LogP algorithm 12.0). n = 3, ±SEM. Projected LogP are given in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0013522#pone-0013522-t001" target="_blank">Table 1</a>.