Virus loads are reduced in the nasal turbinates after treatment with the anti-PR8 IgG preparation.

<p>Unanesthetised BALB/c mice (n = 4) were given 500 pfu of PR8 virus in 10 µl by the intranasal route to establish a localised URT infection. Twenty four hours post-infection, mice were treated with 200 µg, 150 µg, 100 µg or 50 µg of (A) anti-PR8 IgG or non-immune IgG or (B) anti-PR8 F(ab')₂ or non-immune F(ab')₂ or PBS via the URT route. Five days post-infection, mice were killed and nasal turbinates were collected in 1 ml media. Viral titers were determined by plaque assay on MDCK cell monolayers. The experiment was performed once with 4 mice per group, the organs assayed in quadruplicate and titers averaged to provide a value for that animal. Each symbol represents an individual mouse and the line represents the mean of each group. The bracket with an asterisk indicates a statistically significant difference between the indicated groups.