Survival, weight, and clasping response in R6/2 mice treated with TP-10 or vehicle.

<p>(<b>A</b>) Kaplan-Meyer analysis of survival. R6/2 mice treated with TP-10 had a mean survival time that was significantly (p<0.0001) longer than that of R6/2 mice treated with vehicle. (<b>B</b>) Weight as a function of age in the wild type and R6/2 mice. The wild type mice gained weight throughout the course of the study, whereas the R6/2 mice progressively lost weight. There was no statistically significant effect of TP-10 treatment in either genotype. (<b>C</b>) The development of the hind-limb clasping phenotype in R6/2 mice treated with TP-10 or vehicle. Two way analysis of variance indicated a statistically significant effect of treatment (F(1,12) = 8,86, p<0.0116) and age (F(6,72) = 25,32, p<0.0000). Post hoc analysis indicated that the TP-10 treated mice showed significantly less clasping at weeks 10, 11, and 12 (*, p<0.01).