The representative sections depicting the inflammation and demyelination in the lumbar spinal cord of EAE mice by PBS and berberine treatment.

<p>Inflammatory infiltration was widespread in the PBS-treated EAE mice (A), but which was attenuated by berberine treatment (B). A large plaque of demyelination was seen in the PBS-treated EAE mice (C), and demyelination was attenuated in berberine-treated EAE mice (D). a-d were higher magnification views of the boxed areas in A, B, C and D, respectively. A-D: ×40; a-d: ×400.