Mitochondrial uncoupling suppressed TPA-induced p53 mitochondrial translocation in 308 cells.

Blocking mitochondrial permeability transition prevents p53 mitochondrial translocation during skin tumor promotion

Liu, Jianfeng
St. Clair, Daret K.
Gu, Xin
Zhao, Yunfeng

April 2008

AbstractThe tumor suppressor p53 can translocate into mitochondria and activate apoptosis. Here we s...

Mitochondrial apoptotic priming is a key determinant of cell fate upon p53 restoration

Sánchez-Rivera, Francisco J
Ryan, Jeremy
Soto-Feliciano, Yadira M
Clare Beytagh, Mary
Xuan, Lucius
Feldser, David M
Hemann, Michael T
Zamudio, Jesse
Dimitrova, Nadya
Letai, Anthony
Jacks, Tyler

July 2021

Reactivation of p53 in established tumors typically results in one of two cell fates, cell cycle arr...

Blocking mitochondrial permeability transition prevents p53 mitochondrial translocation during skin tumor promotion

Liu, Jianfeng
St. Clair, Daret K.
Gu, Xin
Zhao, Yunfeng

April 2008

AbstractThe tumor suppressor p53 can translocate into mitochondria and activate apoptosis. Here we s...

Mitochondrial uncoupling suppressed TPA-induced p53 mitochondrial translocation in JB6 P+ cells.

Fei Wang (19534)
Xueqi Fu (333099)
Xia Chen (299366)
Xinbin Chen (196609)
Yunfeng Zhao (244764)

February 2013

(A) Immunofluorescent staining of p53 at 30 min after TPA treatment. First panel: p53 detected wi...

Mitochondrial uncoupling prevented mitochondrial dysfunction and apoptosis associated with p53 mitochondrial translocation in JB6 P+ cells.

Fei Wang (19534)
Xueqi Fu (333099)
Xia Chen (299366)
Xinbin Chen (196609)
Yunfeng Zhao (244764)

February 2013

(A) ROS levels. (B) Mitochondrial complex I activities. (C) Mitochondrial membrane potential. (D)...

TPA induced p53 mitochondrial translocation, mitochondrial dysfunction and apoptosis in JB6 P+ cells.

Fei Wang (19534)
Xueqi Fu (333099)
Xia Chen (299366)
Xinbin Chen (196609)
Yunfeng Zhao (244764)

February 2013

WC: wild-type JB6 P+ cells treated with DMSO (control); WT: wild-type JB6 P+ cells treated with 1...

UCP2 knockdown enhanced p53 mitochondrial translocation and decreased colony formation in response to TPA treatment.

Fei Wang (19534)
Xueqi Fu (333099)
Xia Chen (299366)
Xinbin Chen (196609)
Yunfeng Zhao (244764)

February 2013

(A) UCP2 knockdown efficiency examined by Western blot analysis. (B) p53 mitochondrial translocat...

TNF-α induced p53 translocation to mitochondria.

Nathalie Vadrot (315152)
Sarita Ghanem (315153)
Françoise Braut (315154)
Laura Gavrilescu (315155)
Nathalie Pilard (147384)
Abdellah Mansouri (315156)
Richard Moreau (240508)
Florence Reyl-Desmars (315157)

February 2013

(A) Accumulation of p53 was investigated by Western Blot using p53 antibody in lysate from cells ...

TPA-induced modification of p53 residue 378 moderates the suppression of K14 expression.

Bi-He Cai (314689)
Pei-Ching Hsu (314691)
I-Lun Hsin (314693)
Chung-Faye Chao (314696)
Mei-Hua Lu (314699)
Hwang-Chi Lin (314701)
Shih-Hwa Chiou (39111)
Pao-Luh Tao (314703)
Jang-Yi Chen (314705)

February 2013

(A) C9 cells were treated with DMSO or TPA, and total protein was isolated and blotted with diffe...

p53 inhibition by siRNAs and phosphoSer15p53 antibody prevented the reversion of mtDNA depletion.

Nathalie Vadrot (315152)
Sarita Ghanem (315153)
Françoise Braut (315154)
Laura Gavrilescu (315155)
Nathalie Pilard (147384)
Abdellah Mansouri (315156)
Richard Moreau (240508)
Florence Reyl-Desmars (315157)

February 2013

(A) All siRNA transfections were performed with 12.5 nM siRNAs directed against p53 mRNA (p53 siR...

p53 activity is up-regulated after TPA treatment in C9 cells.

Bi-He Cai (314689)
Pei-Ching Hsu (314691)
I-Lun Hsin (314693)
Chung-Faye Chao (314696)
Mei-Hua Lu (314699)
Hwang-Chi Lin (314701)
Shih-Hwa Chiou (39111)
Pao-Luh Tao (314703)
Jang-Yi Chen (314705)

February 2013

C9 cells were treated with DMSO (control) or TPA (100 ng/mL). Compared to the DMSO-treated sample...

p53 is cleaved by caspases generating fragments localizing to mitochondria

Sayan, Berna S.
Sayan, A. Emre
Knight, Richard A.
Melino, Gerry
Cohen, Gerald M.

May 2006

The p53 tumor suppressor protein exerts most of its anti-tumorigenic activity by transcriptionally a...

p53 and Mitochondrial DNA Their Role in Mitochondrial Homeostasis and Toxicity of Antiretrovirals

Koczor, Christopher A.
White, Richard C.
Zhao, Peter
Zhu, Linjue
Fields, Earl
Lewis, William

June 2012

The roles and actions of the tumor suppressor protein p53 have been extensively studied with regard ...

Hypoxia death stimulus induces translocation of p53 protein to mitochondria Detection by immunofluorescence on whole cells

Sansome, Christine
Zaika, Alex
Marchenko, Natalie D
Moll, Ute M

January 2001

AbstractEvidence suggests that p53 induces cell death by a dual mode of action involving activation ...

TNF-α induced p53 interaction to GSK3β, TFAM and D-loop.

Nathalie Vadrot (315152)
Sarita Ghanem (315153)
Françoise Braut (315154)
Laura Gavrilescu (315155)
Nathalie Pilard (147384)
Abdellah Mansouri (315156)
Richard Moreau (240508)
Florence Reyl-Desmars (315157)

February 2013

Cells were treated for 0 (zero-time control) or 1 h with 30 ng/ml TNF-α. Mitochondrial fractions ...

Blocking mitochondrial permeability transition prevents p53 mitochondrial translocation during skin tumor promotion

Liu, Jianfeng
St. Clair, Daret K.
Gu, Xin
Zhao, Yunfeng

April 2008

AbstractThe tumor suppressor p53 can translocate into mitochondria and activate apoptosis. Here we s...

Mitochondrial apoptotic priming is a key determinant of cell fate upon p53 restoration

Sánchez-Rivera, Francisco J
Ryan, Jeremy
Soto-Feliciano, Yadira M
Clare Beytagh, Mary
Xuan, Lucius
Feldser, David M
Hemann, Michael T
Zamudio, Jesse
Dimitrova, Nadya
Letai, Anthony
Jacks, Tyler

July 2021

Reactivation of p53 in established tumors typically results in one of two cell fates, cell cycle arr...

Blocking mitochondrial permeability transition prevents p53 mitochondrial translocation during skin tumor promotion

Liu, Jianfeng
St. Clair, Daret K.
Gu, Xin
Zhao, Yunfeng

April 2008

AbstractThe tumor suppressor p53 can translocate into mitochondria and activate apoptosis. Here we s...

Mitochondrial uncoupling suppressed TPA-induced p53 mitochondrial translocation in JB6 P+ cells.

Fei Wang (19534)
Xueqi Fu (333099)
Xia Chen (299366)
Xinbin Chen (196609)
Yunfeng Zhao (244764)

February 2013

(A) Immunofluorescent staining of p53 at 30 min after TPA treatment. First panel: p53 detected wi...

Mitochondrial uncoupling prevented mitochondrial dysfunction and apoptosis associated with p53 mitochondrial translocation in JB6 P+ cells.

Fei Wang (19534)
Xueqi Fu (333099)
Xia Chen (299366)
Xinbin Chen (196609)
Yunfeng Zhao (244764)

February 2013

(A) ROS levels. (B) Mitochondrial complex I activities. (C) Mitochondrial membrane potential. (D)...

TPA induced p53 mitochondrial translocation, mitochondrial dysfunction and apoptosis in JB6 P+ cells.

Fei Wang (19534)
Xueqi Fu (333099)
Xia Chen (299366)
Xinbin Chen (196609)
Yunfeng Zhao (244764)

February 2013

WC: wild-type JB6 P+ cells treated with DMSO (control); WT: wild-type JB6 P+ cells treated with 1...

UCP2 knockdown enhanced p53 mitochondrial translocation and decreased colony formation in response to TPA treatment.

Fei Wang (19534)
Xueqi Fu (333099)
Xia Chen (299366)
Xinbin Chen (196609)
Yunfeng Zhao (244764)

February 2013

(A) UCP2 knockdown efficiency examined by Western blot analysis. (B) p53 mitochondrial translocat...

TNF-α induced p53 translocation to mitochondria.

Nathalie Vadrot (315152)
Sarita Ghanem (315153)
Françoise Braut (315154)
Laura Gavrilescu (315155)
Nathalie Pilard (147384)
Abdellah Mansouri (315156)
Richard Moreau (240508)
Florence Reyl-Desmars (315157)

February 2013

(A) Accumulation of p53 was investigated by Western Blot using p53 antibody in lysate from cells ...

TPA-induced modification of p53 residue 378 moderates the suppression of K14 expression.

Bi-He Cai (314689)
Pei-Ching Hsu (314691)
I-Lun Hsin (314693)
Chung-Faye Chao (314696)
Mei-Hua Lu (314699)
Hwang-Chi Lin (314701)
Shih-Hwa Chiou (39111)
Pao-Luh Tao (314703)
Jang-Yi Chen (314705)

February 2013

(A) C9 cells were treated with DMSO or TPA, and total protein was isolated and blotted with diffe...

p53 inhibition by siRNAs and phosphoSer15p53 antibody prevented the reversion of mtDNA depletion.

Nathalie Vadrot (315152)
Sarita Ghanem (315153)
Françoise Braut (315154)
Laura Gavrilescu (315155)
Nathalie Pilard (147384)
Abdellah Mansouri (315156)
Richard Moreau (240508)
Florence Reyl-Desmars (315157)

February 2013

(A) All siRNA transfections were performed with 12.5 nM siRNAs directed against p53 mRNA (p53 siR...

p53 activity is up-regulated after TPA treatment in C9 cells.

Bi-He Cai (314689)
Pei-Ching Hsu (314691)
I-Lun Hsin (314693)
Chung-Faye Chao (314696)
Mei-Hua Lu (314699)
Hwang-Chi Lin (314701)
Shih-Hwa Chiou (39111)
Pao-Luh Tao (314703)
Jang-Yi Chen (314705)

February 2013

C9 cells were treated with DMSO (control) or TPA (100 ng/mL). Compared to the DMSO-treated sample...

p53 is cleaved by caspases generating fragments localizing to mitochondria

Sayan, Berna S.
Sayan, A. Emre
Knight, Richard A.
Melino, Gerry
Cohen, Gerald M.

May 2006

The p53 tumor suppressor protein exerts most of its anti-tumorigenic activity by transcriptionally a...

p53 and Mitochondrial DNA Their Role in Mitochondrial Homeostasis and Toxicity of Antiretrovirals

Koczor, Christopher A.
White, Richard C.
Zhao, Peter
Zhu, Linjue
Fields, Earl
Lewis, William

June 2012

The roles and actions of the tumor suppressor protein p53 have been extensively studied with regard ...

Hypoxia death stimulus induces translocation of p53 protein to mitochondria Detection by immunofluorescence on whole cells

Sansome, Christine
Zaika, Alex
Marchenko, Natalie D
Moll, Ute M

January 2001

AbstractEvidence suggests that p53 induces cell death by a dual mode of action involving activation ...

TNF-α induced p53 interaction to GSK3β, TFAM and D-loop.

Nathalie Vadrot (315152)
Sarita Ghanem (315153)
Françoise Braut (315154)
Laura Gavrilescu (315155)
Nathalie Pilard (147384)
Abdellah Mansouri (315156)
Richard Moreau (240508)
Florence Reyl-Desmars (315157)

February 2013

Cells were treated for 0 (zero-time control) or 1 h with 30 ng/ml TNF-α. Mitochondrial fractions ...

Blocking mitochondrial permeability transition prevents p53 mitochondrial translocation during skin tumor promotion

Liu, Jianfeng
St. Clair, Daret K.
Gu, Xin
Zhao, Yunfeng

April 2008

AbstractThe tumor suppressor p53 can translocate into mitochondria and activate apoptosis. Here we s...

Mitochondrial apoptotic priming is a key determinant of cell fate upon p53 restoration

Sánchez-Rivera, Francisco J
Ryan, Jeremy
Soto-Feliciano, Yadira M
Clare Beytagh, Mary
Xuan, Lucius
Feldser, David M
Hemann, Michael T
Zamudio, Jesse
Dimitrova, Nadya
Letai, Anthony
Jacks, Tyler

July 2021

Reactivation of p53 in established tumors typically results in one of two cell fates, cell cycle arr...

Blocking mitochondrial permeability transition prevents p53 mitochondrial translocation during skin tumor promotion

Liu, Jianfeng
St. Clair, Daret K.
Gu, Xin
Zhao, Yunfeng

April 2008

AbstractThe tumor suppressor p53 can translocate into mitochondria and activate apoptosis. Here we s...

Mitochondrial uncoupling suppressed TPA-induced p53 mitochondrial translocation in 308 cells.

Abstract

Extracted data

Mitochondrial uncoupling suppressed TPA-induced p53 mitochondrial translocation in 308 cells.

Abstract

Extracted data

Related items

Related items