<p><b>left</b>: The lung from an LVS-immunized mouse killed at day 7 post challenge showing severe subacute bronchopneumonia. The alveolar spaces are filled with large numbers of intact and degenerated neutrophils (arrows) admixed with small numbers of mononuclear cells. (<b>right</b>) the lung from a <i>clpB</i>-immunized mouse killed at day 7 post challenge showing the infiltration of predominantly mononuclear cells (arrowheads) with virtually no neutrophils in the peribronchial area. H&E, x400.</p
<p>Mice were mock-infected (panel A) or infected with APMV-1 (panel B), APMV-2 (panel C), APMV-3 (pa...
<p>Groups of 3 mice were infected intranasally using 200 TCID50 of WT or ΔF2 Nig06 virus. Mice were ...
Vaccinated outbred SW and inbred C57BL/6 mice handle the progression and outcome of tularemia diseas...
<p>[A] Large areas of pulmonary necrosis (arrowheads) developed in mice sham-vaccinated and infected...
<p>BALB/c mice were infected with 1×10<sup>7</sup> CFU of the <i>F. tularensis</i> LVS, <i>FTL_0325<...
<p>(A) BMDMs (2.5×10<sup>5</sup> cells/well) from wild-type (C57BL/6) mice and their mutant counterp...
causes severe pulmonary disease, and nasal vaccination could be the ideal measure to effectively pr...
<p>Separated mice (n = 4 mice/group) from each group were sacrificed 6 or 7 days post challenge, and...
<p>(A) Groups of 3–4 mice from the indicated strains were infected intranasally with 6,000 CFU of LV...
<p>The strains used for aerosol challenge (Schu S4 WT, CipR, and <i>kdsD</i>::<i>ltrB</i><sub><i>L1<...
<p><b>(A)</b> Groups of B6 or CD1d<sup>-/-</sup> mice were infected i.n. with LVS. On d7 p.i., lungs...
Francisella tularensis causes severe pulmonary disease, and nasal vaccination could be the ideal mea...
<p>To assess lung damage and pulmonary inflammation throughout the course of virus infection, we eva...
<p>Lungs from nonimmunized mice (<b>A</b>), from saline immunized mice (<b>B</b>) and from intranasa...
<p>VC (A, B) and GO 162 μg/mouse (C, D, E, F). (A and B) No pathological changes. (C) Patchy appeara...
<p>Mice were mock-infected (panel A) or infected with APMV-1 (panel B), APMV-2 (panel C), APMV-3 (pa...
<p>Groups of 3 mice were infected intranasally using 200 TCID50 of WT or ΔF2 Nig06 virus. Mice were ...
Vaccinated outbred SW and inbred C57BL/6 mice handle the progression and outcome of tularemia diseas...
<p>[A] Large areas of pulmonary necrosis (arrowheads) developed in mice sham-vaccinated and infected...
<p>BALB/c mice were infected with 1×10<sup>7</sup> CFU of the <i>F. tularensis</i> LVS, <i>FTL_0325<...
<p>(A) BMDMs (2.5×10<sup>5</sup> cells/well) from wild-type (C57BL/6) mice and their mutant counterp...
causes severe pulmonary disease, and nasal vaccination could be the ideal measure to effectively pr...
<p>Separated mice (n = 4 mice/group) from each group were sacrificed 6 or 7 days post challenge, and...
<p>(A) Groups of 3–4 mice from the indicated strains were infected intranasally with 6,000 CFU of LV...
<p>The strains used for aerosol challenge (Schu S4 WT, CipR, and <i>kdsD</i>::<i>ltrB</i><sub><i>L1<...
<p><b>(A)</b> Groups of B6 or CD1d<sup>-/-</sup> mice were infected i.n. with LVS. On d7 p.i., lungs...
Francisella tularensis causes severe pulmonary disease, and nasal vaccination could be the ideal mea...
<p>To assess lung damage and pulmonary inflammation throughout the course of virus infection, we eva...
<p>Lungs from nonimmunized mice (<b>A</b>), from saline immunized mice (<b>B</b>) and from intranasa...
<p>VC (A, B) and GO 162 μg/mouse (C, D, E, F). (A and B) No pathological changes. (C) Patchy appeara...
<p>Mice were mock-infected (panel A) or infected with APMV-1 (panel B), APMV-2 (panel C), APMV-3 (pa...
<p>Groups of 3 mice were infected intranasally using 200 TCID50 of WT or ΔF2 Nig06 virus. Mice were ...
Vaccinated outbred SW and inbred C57BL/6 mice handle the progression and outcome of tularemia diseas...