Quantitation of microgliosis by CD11b immunoreactivity.

<p>pABri treatment reduced CD11b immunoreactivity compared to Tg controls in both the hippocampus and cortex. A and B show representative sections of the hippocampus in a Tg control (A) and a pABri treated Tg mouse (B). C shows semiquantitative analysis of CD11b in the hippocampus (p<0.05 pABri Tg versus Tg controls; p<0.05 wild-type controls versus Tg controls). D shows semiquantitative analysis of CD11b in the cortex (p<0.05 pABri Tg versus Tg controls; p<0.01 wild-type controls versus Tg controls). Wild-type controls did not differ significant from pABri Tg mice in either the cortex or the hippocampus, although there was a trend for controls to have less CD11b immunostaining.