Tumor growth.

<p>A) The effects of Top216 on the growth of A2780 tumor xenografts. Tumor volume was determined by microCT. Mice were treated with Top216 (50 mg/kg) or vehicle at 0 and 48 hours. *) P<0.05, **) P<0.01 vs. baseline and ^{# # #}) P<0.001 vs. control. n = 15 tumors per group. B) Changes in tumor volume assessed by ratio Day 5/baseline in the control group as a function of baseline FLT uptake. n = 7 tumors. R² = 0.61, P = 0.04.