Models of regulatory interactions involving c-Myc, E2F1 and miRNAs.

<p><b>(A) Regulatory network between c-Myc, E2F1 and miRNAs.</b> The interactions among c-Myc, E2F1 and miRNAs are shown. Bidirectional arrows indicate a transcriptional regulation. MiR-17-5p, miR-20a, miR-9, miR-9* and miR-34b are involved on c-Myc activation, on the other hand c-Myc itself regulates their expression. Further, miR-17–5p and miR-20a have been shown to inhibit E2F1 translation. E2F1 can induce miR-17-5p and miR-20a expression. <b>(B) Proposed model involving c-Myc, E2F1 and miRNAs in </b><b><i>MYC</i></b><b> translocation-negative BL.</b> MiR-34b and miR-9* down-regulation induces c-Myc expression directly or by E2F1 induction, respectively. c-Myc over-expression possibly determines up-regulation of miR-17-5p, miR-20a and miR-9.