Intraperitoneal LPS does not stimulate inflammation in the endometrium.

<p>Representative photomicrographs of cross sections of uteri collected from wild type (WT) mice 24 h after intraperitoneal infusion with 100 µl of vehicle (A, B) or 100 µg ultrapure LPS from <i>E. coli</i> O111:B4 (C, D), and Tlr4^−/− mice similarly infused intraperitoneal with 100 µl vehicle (E, F) or 100 µg LPS (G, H). Cross sections of the uterus (A, C, E, G) or the peritoneal mesentery adjacent to the uterus (B, D, F, H) were stained with haematoxylin and eosin, and images collected at 10X magnification (bars = 200 µm). At least 4 sections per animal and at least 4 fields per section were examined. There was no evidence of inflammation of the endometrium. However, WT mice treated with LPS had evidence of inflammation of the peritoneal mesentery with hyperaemia, extravasations of red blood cells and accumulation of granulocytes (D).