<p>Second codon positions show low variability due to purifying selection on non-synonymous changes. 4-fold degenerate positions vary between 5% and 97% GC among published genomes. In the classical neutral scenario (red), 4-fold degenerate positions are nearly neutral and their composition results essentially from mutational patterns. These patterns are modified in bacteria that lose repair genes, such as mutators, which show additional AT pressure (grey area) <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1001104#pgen.1001104-Lind1" target="_blank">[19]</a>. In the selectionist view (blue), the composition of 4-fold degenerate positions results from selection for GC content, the mutational patterns are AT-rich r...
<div><p>The characterization of functional elements in genomes relies on the identification of the f...
Here I show that the mean codon usage bias of a genome, and of the lowly expressed genes in a genome...
The characterization of functional elements in genomes relies on the identification of the footprint...
International audienceThe dissection of natural selection and neutral processes remains a core probl...
The dissection of natural selection and neutral processes remains a core problem for molecular evolu...
<p>In GC-rich genomes 3<sup>rd</sup> codon positions are even more GC-rich than intergenic regions, ...
BackgroundCorrelations between genome composition (in terms of GC content) and usage of particular c...
The major codon preference model suggests that codons read by tRNAs in high concentrations are prefe...
The genomic GC-content of bacteria varies dramatically, from less than 20% to more than 70%. This va...
The major codon preference model suggests that codons read by tRNAs in high concentrations are prefe...
The genomic GC-content of bacteria varies dramatically, from less than 20% to more than 70%. This va...
Background: In spite of extensive research on the effect of mutation and selection on codon usage, a...
In spite of extensive research on the effect of mutation and selection on codon usage, a general mod...
Codon usage bias patterns have been broadly explored for many viruses. However, the relative importa...
Mammalian genomes consist of regions differing in GC content, referred to as isochores or GC-content...
<div><p>The characterization of functional elements in genomes relies on the identification of the f...
Here I show that the mean codon usage bias of a genome, and of the lowly expressed genes in a genome...
The characterization of functional elements in genomes relies on the identification of the footprint...
International audienceThe dissection of natural selection and neutral processes remains a core probl...
The dissection of natural selection and neutral processes remains a core problem for molecular evolu...
<p>In GC-rich genomes 3<sup>rd</sup> codon positions are even more GC-rich than intergenic regions, ...
BackgroundCorrelations between genome composition (in terms of GC content) and usage of particular c...
The major codon preference model suggests that codons read by tRNAs in high concentrations are prefe...
The genomic GC-content of bacteria varies dramatically, from less than 20% to more than 70%. This va...
The major codon preference model suggests that codons read by tRNAs in high concentrations are prefe...
The genomic GC-content of bacteria varies dramatically, from less than 20% to more than 70%. This va...
Background: In spite of extensive research on the effect of mutation and selection on codon usage, a...
In spite of extensive research on the effect of mutation and selection on codon usage, a general mod...
Codon usage bias patterns have been broadly explored for many viruses. However, the relative importa...
Mammalian genomes consist of regions differing in GC content, referred to as isochores or GC-content...
<div><p>The characterization of functional elements in genomes relies on the identification of the f...
Here I show that the mean codon usage bias of a genome, and of the lowly expressed genes in a genome...
The characterization of functional elements in genomes relies on the identification of the footprint...