Neurogenesis in the olfactory epithelium after regeneration.

<p>Mean density of Ki 67 (A, B), caspase 3 (C, D), GAP 43 (E, F) and OMP (G, H) positive cells in the olfactory epithelium of WT and STOP null mice at two different ages. In the 3-month-old groups (A, C, E, G), apoptotic, proliferating and immature, but not mature neurons are more numerous in STOP null mice as compared to WT mice, both in control animals and after regeneration. In the 10-month-old groups (B, D, F, H) only the number of caspase 3 positive neurons (D) was increased in STOP null mice as compared to WT mice, in controls and after regeneration. All values are represented as mean +/− SEM, *p<0.05, **p<0.01. The photomicrographs illustrate immunostaining in animals after regeneration. Scale bar: 25 µm.