<p>(A) Experimental setup. Proliferating HEL fibroblasts were treated with sublethal doses of doxorubicin or UV-C radiation. At the indicated times after treatment, cells were infected with HCMV-AD169 and harvested 4 h later. (B) Flow cytometry analysis of DNA content and MIE gene expression, as described in the legend to <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1001096#ppat-1001096-g001" target="_blank">figure 1</a>.</p
Over the past decades it has become increas-ingly clear that the DnA damage response (DDR) plays a c...
<p><b>A and B, E and F</b> HepG2 and Huh7 cells were exposed to 0, 2 or 4 Gy of gamma radiation and ...
The toxic mechanisms of cisplatin have been frequently studied in many species and in vitro cell mod...
<p>(A) Asynchronously proliferating HEL fibroblasts were infected with the indicated HCMV strains at...
<p>The indicated knock-down fibroblasts were treated with doxorubicin (+ Doxo) and infected by HCMV ...
<p>HEL fibroblasts were stably transduced with lentiviruses expressing p53 or GFP-specific shRNAs. T...
<p>(A) Experimental setup. Proliferating HEL fibroblasts were treated with aphidicolin (Aph) or hydr...
<p>(A) Experimental setup. Proliferating HEL fibroblasts and the indicated knock-down derivatives we...
Cancer therapy operates by inflicting damage in malignant cells. The most lethal target is the genom...
The changes in global gene expression in response to DNA damage may derive from either direct induct...
Cells are subjected to multiple types of stress throughout their life cycle, including starvation, i...
<p>A. Fibroblasts (HF-CARs) were infected with RAds expressing IE1 or IE2 at an m.o.i. of 1. Cell su...
Cancers arise as a consequence of the accumulation of multiple genetic mutations in a susceptible ce...
<p>MRC5 cells were transduced with one of the three type 1 LVs and selected by puromycin treatment (...
The dissertation deals with a cell response to genotoxic stress, specifically to anti-cancer treatme...
Over the past decades it has become increas-ingly clear that the DnA damage response (DDR) plays a c...
<p><b>A and B, E and F</b> HepG2 and Huh7 cells were exposed to 0, 2 or 4 Gy of gamma radiation and ...
The toxic mechanisms of cisplatin have been frequently studied in many species and in vitro cell mod...
<p>(A) Asynchronously proliferating HEL fibroblasts were infected with the indicated HCMV strains at...
<p>The indicated knock-down fibroblasts were treated with doxorubicin (+ Doxo) and infected by HCMV ...
<p>HEL fibroblasts were stably transduced with lentiviruses expressing p53 or GFP-specific shRNAs. T...
<p>(A) Experimental setup. Proliferating HEL fibroblasts were treated with aphidicolin (Aph) or hydr...
<p>(A) Experimental setup. Proliferating HEL fibroblasts and the indicated knock-down derivatives we...
Cancer therapy operates by inflicting damage in malignant cells. The most lethal target is the genom...
The changes in global gene expression in response to DNA damage may derive from either direct induct...
Cells are subjected to multiple types of stress throughout their life cycle, including starvation, i...
<p>A. Fibroblasts (HF-CARs) were infected with RAds expressing IE1 or IE2 at an m.o.i. of 1. Cell su...
Cancers arise as a consequence of the accumulation of multiple genetic mutations in a susceptible ce...
<p>MRC5 cells were transduced with one of the three type 1 LVs and selected by puromycin treatment (...
The dissertation deals with a cell response to genotoxic stress, specifically to anti-cancer treatme...
Over the past decades it has become increas-ingly clear that the DnA damage response (DDR) plays a c...
<p><b>A and B, E and F</b> HepG2 and Huh7 cells were exposed to 0, 2 or 4 Gy of gamma radiation and ...
The toxic mechanisms of cisplatin have been frequently studied in many species and in vitro cell mod...