Rac GTPase Activation is Critical for Enhanced NADPH Oxidase Activity and Superoxide Production in the Hippocampal CA1 Region Following GCI.

<p>NSC23766 pre-treatment reduces NADPH oxidase activity (<b>A</b>) and superoxide production (<b>B</b>) at 3 h post-reperfusion in the hippocampus CA1 after GCI. Data for experiments (A) and (B) was measured as optical density (OD) and expressed as fold difference in comparison to sham from four to five animals. *<i>p</i><0.05 vs. sham, ^#<i>p</i><0.05 vs. saline control. HET staining measuring endogenous superoxide production in CA1 coronal brain sections obtained from four to five animals; magnification 40X (<b>C</b>).