The roscovitine-mediated rescue of MIE gene expression in S/G2 cells is p53 independent.

<p>The indicated knock-down fibroblasts were treated with doxorubicin (+ Doxo) and infected by HCMV 24 later. Or cells were treated with 25 µM roscovitine (+ Rosco) and infected with HCMV shortly after the start of treatment, as detailed in <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1001096#ppat-1001096-g008" target="_blank">figure 8C</a>. Cells were harvested at 5 hpi and analyzed for MIE expression and DNA content, as described in the legend to <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1001096#ppat-1001096-g001" target="_blank">figure 1</a>.