Conformational state of guinea pig hemoglobin.

<p>The structure of guinea pig hemoglobin (PDB-code: 3HYU) was superimposed with the structures of three conformational states of human hemoglobin by their C_α-atoms. The guinea pig hemoglobin structure is shown in cartoon representation, which is colored according to the distance between corresponding C_α-atoms in guinea pig hemoglobin and the respective conformational state of human hemoglobin in (A) T-state (PDB-code: 1A3N, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0012389#pone.0012389-Tame1" target="_blank">[36]</a>), (B) R-state (PDB-code: 1HHO, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0012389#pone.0012389-Shaanan1" target="_blank">[37]</a>) and (C) R2-state (PDB-code: 1BBB, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0012389#pone.0012389-Silva1" target="_blank">[10]</a>). Distances between C_α-atoms clearly show that guinea pig hemoglobin crystallizes in the R2-state (C). Color coding of C_α-atoms distances was made according to the colors given in the bar below.