Effect of cell/substrate stiffness on bond rebinding and adhesion lifetime.

<p>(A) The number of closed bonds as a function of time by averaging 1,000 Monte Carlo trajectories for different values of the reduced modulus of the cell and substrate ( and 100). The load level is fixed at 0.5. (B) The cluster lifetime as a function of the reduced modulus for different cluster sizes (). (C) The ratio of total events between bond rebinding and bond rupture influenced by the reduced modulus (). (D) Analytic results of the cluster lifetime for the cases of rigid media (Upper) and zero rebinding (Lower), compared to the Monte Carlo simulations for stiff () and soft () cell and substrate ().