TMV promote expansion of human Treg in culture.

<p>The fold expansion of fresh (<i>left panel</i>) or rapamycin-expanded (<i>right panel</i>) CD4⁺CD25^high T cells to which TMV or DC-derived MV were added on day 0. Cells were stimulated with OKT3, anti-CD28 Abs and IL-2 (500 IU/mL) and cultured for 14–21 d. The data are means ± SD of six independent co-cultures. Asterisks indicate significant differences (p<0.05) between the cultures ± TMV.