Isotopic values of body water relative to model predictions.

<p>Isotopic signature of body water of VEH (○) and STZ (•) mice relative to body water model predictions in which the only model variant is water influx. (A) Measured δ²H relative to δ¹⁸O of body water for all animals over the entire 5-week study period. The curve depicts model predictions for δ²H and δ¹⁸O values over a range of water influx values. (B) Measured δ²H values of body water and (C) δ¹⁸O values of body water relative to average drinking water per day of 9 individual animals (mL/day). The bold curve on each panel indicates values predicted by our mathematical model of the isotopic composition of body water using a total energy expenditure (TEE) of 37.4 KJ/day. Correlations between the model and measured δ²H and δ¹⁸O of body water yielded an r² = 0.83 and r² = 0.79, respectively. The lighter curve on each panel indicates values predicted by our mathematical model of the isotopic composition of body water using a TEE of 65.0 KJ/day. Correlations between the model and measured δ²H and δ¹⁸O of body water yielded an r² = 0.96 and r² = 0.96, respectively. Bars delineate standard deviation for sample analyses.