T-cell depletion during acute SHIV-1157ipEL-p viremia.

<p>The percent CD4⁺ T cells in blood, lymph node and gut was estimated compared with cells from naïve monkeys (closed symbols). Biopsy specimens were collected during the acute phase of infection. Two of the 2-week time points were obtained from last two i.v.-inoculated RM used for viral adaptation, the remainder were collected from RM undergoing the 5x weekly i.r. challenge-dose titration. We assigned peak viremia as being week 2 after the pen-ultimate i.r. inoculation, the one that most likely was successful in achieving systemic infection. Individual time points are shown with different symbols (open squares, week 2; open triangles, week 5; open circles, week 12).