Post transplant administration of AMD3100 improves animal survival in a murine transplantation model.

<p>KTLS cells from C57BL/Ka CD45.1 Thy1.1 mice were injected via tail vein into lethally irradiated C57BL/6 CD45.2 Thy1.2 mice (250 KTLS cells per mouse). Beginning 2 days after transplant (day +2), the mice were injected subcutaneously with PBS control or AMD3100 at 5 mg/kg body weight every Monday, Wednesday, and Friday until day +56. Animal survival was monitored daily. In experiment #1 and #2, the mice received 10.5 Gy total body irradiation using a Cesium irradiator. In experiment #3, the mice received 9.5 Gy total body irradiation. (n = 10 mice in each group in each experiment).