<p><b>A</b>. Staining for pSTAT3 in the mediobasal hypothalamus of mice on a low-fat diet given an intraperitoneal injection of either leptin or vehicle. <b>B</b>. Staining for pSTAT3 in the mediobasal hypothalamus of mice on a high-fat diet given an intraperitoneal injection of either leptin or vehicle. <b>C</b>. Quantitation of pSTAT3 positive cells in the arcuate nucleus for mice on a low-fat diet. <b>D</b>. Quantitation of pSTAT3 positive cells in the arcuate nucleus for mice on a high-fat diet.</p
<div><p>Diet-induced obesity (DIO) resulting from consumption of a high fat diet (HFD) attenuates no...
<p>A–D) Representative immunohistochemistry (IHC) images showing pSTAT3 immunoreactivity following i...
Diet-induced obesity (DIO) resulting from consumption of a high fat diet (HFD) attenuates normal neu...
<p>A. Shown are representative images of double immunohistochemistry for P-STAT3 (DAB) and β-Endorph...
<p>(<b>A</b>) Food intake in chow fed f/f and KO mice after receiving a bolus injection of leptin (5...
<p>Top Row: <i>Pomc-EGFP</i> mice (6-10 wks of age) were given leptin (5 mg/kg, ip, 30 min). Shown i...
<p>C57Bl/6J mice were given diets for 10 weeks and injected with leptin (0.6 mg/kg, 30 minutes). A. ...
Signal transducer and activator of transcription (Stat)-3 signals mediate many of the metabolic effe...
<p>The phosphorylation of STAT3 (A) and FOXO1 (B) in the mediobasal hypothalamus 1 hour after the ic...
SummaryLeptin has pleiotropic effects on glucose homeostasis and feeding behavior. Here, we validate...
Leptin-stimulated Stat3 activation in proopiomelanocortin (POMC)-expressing neurons of the hypothala...
<p>(A) Representative images for western blot experiement on total (t-) and phosphorylated (p-) STAT...
Intraperitoneal leptin administration to wild-type and ob/ob mice caused a prompt activation of Stat...
<p>Activation of STAT3 phosphorylation by leptin in dendrites of hypothalamic AgRP neurons by immuno...
<p>Immuno-EM for pSTAT3 (DAB) in a leptin-treated (4 mg/kg ip; 10 min) <i>Lepr<sup>db/db</sup></i>;<...
<div><p>Diet-induced obesity (DIO) resulting from consumption of a high fat diet (HFD) attenuates no...
<p>A–D) Representative immunohistochemistry (IHC) images showing pSTAT3 immunoreactivity following i...
Diet-induced obesity (DIO) resulting from consumption of a high fat diet (HFD) attenuates normal neu...
<p>A. Shown are representative images of double immunohistochemistry for P-STAT3 (DAB) and β-Endorph...
<p>(<b>A</b>) Food intake in chow fed f/f and KO mice after receiving a bolus injection of leptin (5...
<p>Top Row: <i>Pomc-EGFP</i> mice (6-10 wks of age) were given leptin (5 mg/kg, ip, 30 min). Shown i...
<p>C57Bl/6J mice were given diets for 10 weeks and injected with leptin (0.6 mg/kg, 30 minutes). A. ...
Signal transducer and activator of transcription (Stat)-3 signals mediate many of the metabolic effe...
<p>The phosphorylation of STAT3 (A) and FOXO1 (B) in the mediobasal hypothalamus 1 hour after the ic...
SummaryLeptin has pleiotropic effects on glucose homeostasis and feeding behavior. Here, we validate...
Leptin-stimulated Stat3 activation in proopiomelanocortin (POMC)-expressing neurons of the hypothala...
<p>(A) Representative images for western blot experiement on total (t-) and phosphorylated (p-) STAT...
Intraperitoneal leptin administration to wild-type and ob/ob mice caused a prompt activation of Stat...
<p>Activation of STAT3 phosphorylation by leptin in dendrites of hypothalamic AgRP neurons by immuno...
<p>Immuno-EM for pSTAT3 (DAB) in a leptin-treated (4 mg/kg ip; 10 min) <i>Lepr<sup>db/db</sup></i>;<...
<div><p>Diet-induced obesity (DIO) resulting from consumption of a high fat diet (HFD) attenuates no...
<p>A–D) Representative immunohistochemistry (IHC) images showing pSTAT3 immunoreactivity following i...
Diet-induced obesity (DIO) resulting from consumption of a high fat diet (HFD) attenuates normal neu...