Effect of the AMPK inhibitor compound C on ethanol-induced cardiomyocyte contractile defects.

<p>Freshly isolated cardiomyocytes from FVB mice were incubated with ethanol (240 mg/dl) in the presence or absence of compound C (10 µM) for 2 hrs. A: Resting cell length; B: Peak shortening (normalized to resting cell length); C: Maximal velocity of shortening (+ dL/dt); D: Maximal velocity of relengthening (− dL/dt); E: Time-to-peak shortening (TPS) and F: Time-to-90% relengthening (TR₉₀). Mean ± SEM, n = 59–77 cells from 3 mice per group, * p<0.05 <i>vs.</i> control group, # p<0.05 <i>vs.</i> ethanol (EtOH) group.