Effect of Genz-112638 on whole body glucose metabolism.

<p>Hyperinsulinemic-euglycemic clamps were performed in normal diet (Lean) or HFD (DIO) fed mice treated with Genz-112638 or placebo (water) by daily oral gavage (125 mg/kg/day) for 12 weeks. Animals were continuously infused with [³H]glucose throughout the clamps. A) Insulin-stimulated whole body glucose uptake, B) Insulin-stimulated whole body glycolysis. Data shown as mean ± SEM (n = 10 mice per group). #<i>P</i><0.05 vs. Water Lean, *<i>P</i><0.05 Genz-112638 DIO vs. Water DIO.