Antiviral activity (IC₅₀ and IC₉₀) of RBV against VSV and SeV in different cell types.

<p>The 50% and 90% inhibitory concentrations (IC₅₀ and IC₉₀) for RBV were estimated by means of the plaque reduction (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0011265#pone-0011265-g002" target="_blank">Fig. 2</a>) as described in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0011265#s2" target="_blank">Materials and Methods</a>. Data are expressed as mean without standard error of mean that, however, never exceeded 20% of the mean values. Note that an extremely poor potency of RBV against VSV and SeV in Vero did not allow it to reach IC₉₀ even at 3000 µM RBV concentration (“>3000”).