Mean CVL and New HIV Infections, 2004–2008.

<p>There was a statistically significant decline in annual measures of mean CVL from 2004–2008 (p = 0.037). Newly diagnosed cases of HIV (shown in red with ) decreased in San Francisco from 798 (2004) to 434 (2008) (p<0.005). The point estimates of HIV incidence (shown in dark red with ▵) using the CDC methods also declined from 935 [95% CI 658–1212] in 2006, to 792 [552–1033] in 2007 and 621 [462–781] in 2008, although the change was not statistically significant (trend p = 0.29). The reductions in annual measures of mean CVL were significantly associated with decreases in newly diagnosed and reported HIV cases from 2004–2008 (p = 0.003). Longitudinal reductions in estimated HIV incidence were consistent with the trends in mean and total CVL, but the association in the meta-regression was not statistically significant (p>0.3).