Reduced D2 receptor number in WT mice treated with cocaine.

<p><b>A.</b> D1R number in striatal membranes was not affected by cocaine treatment in either genotype when assessed by saturation binding using [³H]-SCH23390. <b>B.</b> Cocaine treatment reduced D2R number in WT mice (**p<0.01 WT cocaine versus WT saline). Saline treated GASP-1 KO showed reduced D2R number (GASP-1 KO saline versus WT saline where *p<0.05) and D2R number was increased in cocaine treated GASP-1 KO mice (#p<0.05 GASP-1 KO cocaine versus GASP-1 KO saline). D2R number was assessed by saturation binding using [³H]-raclopride. Data shown are normalized to saline treated groups and are from three independent radioligand binding experiments, performed in duplicate, with at least eight mice per group.