Model depicting the inhibition of CSPα chaperone activity by quercetin.
- Fenglian Xu (65214)
- Juliane Proft (266788)
- Sarah Gibbs (256001)
- Bob Winkfein (364101)
- Jadah N. Johnson (364102)
- Naweed Syed (364103)
- Janice E. A. Braun (266819)
Publication date
February 2013
DOIAbstract
<p>The synaptic vesicle protein CSPα has unique anti-neurodegenerative properties. Distinct CSPα complexes exist: inactive, active (in complex with Hsc70 and SGT), and a CSPα dimer. Quercetin promotes the CSPα dimer, inhibits assembly of the active CSPα complex and synaptic transmission.</p
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