Specific TDR patterns and levels for subjects with a M184V/I and/or K65R +/− TAMs.

Max Lataillade (183356)
Jennifer Chiarella (183360)
Rong Yang (107028)
Steven Schnittman (364353)
Victoria Wirtz (364354)
Jonathan Uy (143781)
Daniel Seekins (183368)
Mark Krystal (364355)
Marco Mancini (364356)
Donnie McGrath (364357)
Birgitte Simen (183369)
Michael Egholm (180599)
Michael Kozal (183380)

Publication date

February 2013

DOI

10.1371/journal.pone.0010952.t004

Abstract

VF: Virologic Failure VS: Virologic Success NRTI: Nucleoside Reverse Transcriptase Inhibitor NNRTI: Non-Nucleoside Reverse Transcriptase Inhibitor PI: Protease Inhibitor. TAMs: Thymidine Analogue Mutations. HIV VL: HIV Viral Load. TDRs: Transmitted Drug Resistance Mutations. 6-LPV# has both a M184V and a K65R TDR. Bold: M184V, TAMs, Major PI mutations according to HIV Stanford Database.</p

Extracted data

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Specific TDR patterns and levels for subjects with a M184V/I and/or K65R +/− TAMs.

Max Lataillade (183356)
Jennifer Chiarella (183360)
Rong Yang (107028)
Steven Schnittman (364353)
Victoria Wirtz (364354)
Jonathan Uy (143781)
Daniel Seekins (183368)
Mark Krystal (364355)
Marco Mancini (364356)
Donnie McGrath (364357)
Birgitte Simen (183369)
Michael Egholm (180599)
Michael Kozal (183380)

Open link

Publication date

February 2013

DOI

10.1371/journal.pone.0010952.t004

Abstract

Extracted data

Pouga L.
Santoro M. M.
Charpentier C.
Di Carlo D.
ROMEO, ILARIA
Artese A.
Alcaro S.
Antinori A.
Wirden M.
Perno C. F.
Ambrosio F. A.
Calvez V.
Descamps D.
Marcelin A. -G.
Ceccherini-Silberstein F.
Lambert-Niclot S.

January 2019

Mutations at HIV-1 reverse transcriptase (RT) codon 184 such as M184V confer resistance to two nucle...

Details of mutations found according to antiretroviral family and period of study.

Juan Ambrosioni (749142)
Omar Sued (132831)
David Nicolas (749143)
Marta Parera (749144)
María López-Diéguez (749145)
Anabel Romero (749146)
Fernando Agüero (276046)
María Ángeles Marcos (749147)
Christian Manzardo (341791)
Laura Zamora (232408)
Manuel Gómez-Carrillo (5652313)
José María Gatell (5653063)
Tomás Pumarola (178995)
José María Miró (749148)

June 2015

* Only mutations found in at least one case according to WHO list of TDR are listed.&...

Factors associated with the emergence of K65R in patients with HIV-1 infection treated with combination antiretroviral therapy containing tenofovir

von Wyl, Viktor
Yerly, Sabine
Böni, Jürg
Bürgisser, Philippe
Klimkait, Thomas
Battegay, Manuel
Bernasconi, Enos
Cavassini, Matthias
Furrer, Hansjakob
Hirschel, Bernard
Vernazza, Pietro L
Rickenbach, Martin
Ledergerber, Bruno
Günthard, Huldrych F

January 2008

BACKGROUND: The human immunodeficiency virus type 1 reverse-transcriptase mutation K65R is a single-...

Virologic outcome at Week 48 and specific TDR at Baseline known to affect NRTI Backbone.

Max Lataillade (183356)
Jennifer Chiarella (183360)
Rong Yang (107028)
Steven Schnittman (364353)
Victoria Wirtz (364354)
Jonathan Uy (143781)
Daniel Seekins (183368)
Mark Krystal (364355)
Marco Mancini (364356)
Donnie McGrath (364357)
Birgitte Simen (183369)
Michael Egholm (180599)
Michael Kozal (183380)

February 2013

Thymidine Analog Mutations (TAMs); Virologic Success at week 48 (VS), Virologic Failure at week 4...

Clinical, virological and biochemical evidence supporting the association of HIV-1 reverse transcriptase polymorphism R284K and thymidine analogue resistance mutations M41L, L210W and T215Y in patients failing tenofovir/emtricitabine therapy

Betancor, Gilberto
Garriga, César
Puertas, Maria C.
Nevot, Maria
Anta, Lourdes
Blanco, José L.
Pérez Elías, M. Jesús
Mendoza, Carmen de
Martínez, Miguel A.
Martínez Picado, Francisco Javier
Menéndez-Arias, Luis
Spanish AIDS Research Network (ResRIS)

Background: Thymidine analogue resistance mutations (TAMs) selected under treatment with nucleoside ...

Mutational Correlates of Virological Failure in Individuals Receiving a WHO-Recommended Tenofovir-Containing First-Line Regimen: An International Collaboration

Rhee, SY
Varghese, V
Holmes, SP
Van Zyl, GU
Steegen, K
Boyd, MA
Cooper, DA
Nsanzimana, S
Saravanan, S
Charpentier, C
de Oliveira, T
Etiebet, MA
Garcia, F
Goedhals, D
Gomes, P
Günthard, HF
Hamers, RL
Hoffmann, CJ
Hunt, G
Jiamsakul, A
Kaleebu, P
Kanki, P
Kantor, R
Kerschberger, B
Marconi, VC
D'amour Ndahimana, J
Ndembi, N
Ngo-Giang-Huong, N
Rokx, C
Santoro, MM
Schapiro, JM
Schmidt, D
Seu, L
Sigaloff, KCE
Sirivichayakul, S
Skhosana, L
Sunpath, H
Tang, M
Yang, C
Carmona, S
Gupta, RK
Shafer, RW

March 2017

Tenofovir disoproxil fumarate (TDF) genotypic resistance defined by K65R/N and/or K70E/Q/G occurs in...

Prevalence of low and high abundance Transmitted Drug Resistance Mutations (TDRs) by antiretroviral drug class.

Max Lataillade (183356)
Jennifer Chiarella (183360)
Rong Yang (107028)
Steven Schnittman (364353)
Victoria Wirtz (364354)
Jonathan Uy (143781)
Daniel Seekins (183368)
Mark Krystal (364355)
Marco Mancini (364356)
Donnie McGrath (364357)
Birgitte Simen (183369)
Michael Egholm (180599)
Michael Kozal (183380)

February 2013

N(t)RTI(s)- nucleoside(tide) reverse transcriptase inhibitor; NNRTI – non-nucleoside rever...

Mutational Correlates of Virological Failure in Individuals Receiving a WHO-Recommended Tenofovir-Containing First-Line Regimen: An International Collaboration.

Rhee, Soo-Yon
Varghese, Vici
Holmes, Susan P
Van Zyl, Gert U
Steegen, Kim
Boyd, Mark A
Cooper, David A
Nsanzimana, Sabin
Saravanan, Shanmugam
Charpentier, Charlotte
de Oliveira, Tulio
Etiebet, Mary-Ann A
Garcia, Federico
Goedhals, Dominique
Gomes, Perpetua
Günthard, Huldrych F
Hamers, Raph L
Hoffmann, Christopher J
Hunt, Gillian
Jiamsakul, Awachana
Kaleebu, Pontiano
Kanki, Phyllis
Kantor, Rami
Kerschberger, Bernhard
Marconi, Vincent C
D'amour Ndahimana, Jean
Ndembi, Nicaise
Ngo-Giang-Huong, Nicole
Rokx, Casper
Santoro, Maria M
Schapiro, Jonathan M
Schmidt, Daniel
Seu, Lillian
Sigaloff, Kim C E
Sirivichayakul, Sunee
Skhosana, Lindiwe
Sunpath, Henry
Tang, Michele
Yang, Chunfu
Carmona, Sergio
Gupta, Ravindra K
Shafer, Robert W

March 2017

Tenofovir disoproxil fumarate (TDF) genotypic resistance defined by K65R/N and/or K70E/Q/G occurs in...

Transmitted Drug Resistance by ARV Class and Virologic Outcome.

Max Lataillade (183356)
Jennifer Chiarella (183360)
Rong Yang (107028)
Steven Schnittman (364353)
Victoria Wirtz (364354)
Jonathan Uy (143781)
Daniel Seekins (183368)
Mark Krystal (364355)
Marco Mancini (364356)
Donnie McGrath (364357)
Birgitte Simen (183369)
Michael Egholm (180599)
Michael Kozal (183380)

February 2013

Transmitted Drug Resistance by ARV Class and Virologic Outcome: Note: TDRs are not mutually exclu...

Predicted susceptibility to antiretroviral drugs of the 71 viruses carrying TDR mutations.

Gonzalo Yebra (294031)
Miguel de Mulder (294030)
María Jesús Pérez-Elías (192940)
José Antonio Pérez-Molina (189507)
Juan Carlos Galán (178955)
Jara Llenas-García (341262)
Santiago Moreno (90184)
África Holguín (3273111)

February 2013

Susceptibility was estimated according to the HIVdb Interpretation Algorithm (Stanford University...

HIV-1 viral load is elevated in individuals with reverse transcriptase mutation M184V/I during virological failure of first line antiretroviral therapy and is associated with compensatory mutation L74I

Gupta, Ravindra
gregson, john
deenan, pillay
rawlings, datir
carlo, perno
Robert, Shafer
Anne, Derache

November 2019

Background: M184V/I cause high-level lamivudine (3TC) and emtricitabine (FTC) resistance, and increa...

Emergence of mutations.

Alexandra U. Scherrer (214775)
Jürg Böni (36157)
Sabine Yerly (82534)
Thomas Klimkait (178911)
Vincent Aubert (297526)
Hansjakob Furrer (93994)
Alexandra Calmy (36005)
Matthias Cavassini (146654)
Luigia Elzi (297529)
Pietro L. Vernazza (191358)
Enos Bernasconi (174329)
Bruno Ledergerber (93996)
Huldrych F. Günthard (173082)

February 2013

Accumulation of nucleoside reverse transcriptase inhibitor (NRTI) mutations after virological fai...

New resistance mutations to nucleoside reverse transcriptase inhibitors at codon 184 of HIV-1 reverse transcriptase (M184L and M184T)

Pouga L.
Santoro M. M.
Charpentier C.
Di Carlo D.
ROMEO, ILARIA
Artese A.
Alcaro S.
Antinori A.
Wirden M.
Perno C. F.
Ambrosio F. A.
Calvez V.
Descamps D.
Marcelin A. -G.
Ceccherini-Silberstein F.
Lambert-Niclot S.

January 2019

Mutations at HIV-1 reverse transcriptase (RT) codon 184 such as M184V confer resistance to two nucle...

Details of mutations found according to antiretroviral family and period of study.

Juan Ambrosioni (749142)
Omar Sued (132831)
David Nicolas (749143)
Marta Parera (749144)
María López-Diéguez (749145)
Anabel Romero (749146)
Fernando Agüero (276046)
María Ángeles Marcos (749147)
Christian Manzardo (341791)
Laura Zamora (232408)
Manuel Gómez-Carrillo (5652313)
José María Gatell (5653063)
Tomás Pumarola (178995)
José María Miró (749148)

June 2015

* Only mutations found in at least one case according to WHO list of TDR are listed.&...

Factors associated with the emergence of K65R in patients with HIV-1 infection treated with combination antiretroviral therapy containing tenofovir

von Wyl, Viktor
Yerly, Sabine
Böni, Jürg
Bürgisser, Philippe
Klimkait, Thomas
Battegay, Manuel
Bernasconi, Enos
Cavassini, Matthias
Furrer, Hansjakob
Hirschel, Bernard
Vernazza, Pietro L
Rickenbach, Martin
Ledergerber, Bruno
Günthard, Huldrych F

January 2008

BACKGROUND: The human immunodeficiency virus type 1 reverse-transcriptase mutation K65R is a single-...

Virologic outcome at Week 48 and specific TDR at Baseline known to affect NRTI Backbone.

Max Lataillade (183356)
Jennifer Chiarella (183360)
Rong Yang (107028)
Steven Schnittman (364353)
Victoria Wirtz (364354)
Jonathan Uy (143781)
Daniel Seekins (183368)
Mark Krystal (364355)
Marco Mancini (364356)
Donnie McGrath (364357)
Birgitte Simen (183369)
Michael Egholm (180599)
Michael Kozal (183380)

February 2013

Thymidine Analog Mutations (TAMs); Virologic Success at week 48 (VS), Virologic Failure at week 4...

Betancor, Gilberto
Garriga, César
Puertas, Maria C.
Nevot, Maria
Anta, Lourdes
Blanco, José L.
Pérez Elías, M. Jesús
Mendoza, Carmen de
Martínez, Miguel A.
Martínez Picado, Francisco Javier
Menéndez-Arias, Luis
Spanish AIDS Research Network (ResRIS)

Background: Thymidine analogue resistance mutations (TAMs) selected under treatment with nucleoside ...

Mutational Correlates of Virological Failure in Individuals Receiving a WHO-Recommended Tenofovir-Containing First-Line Regimen: An International Collaboration

Rhee, SY
Varghese, V
Holmes, SP
Van Zyl, GU
Steegen, K
Boyd, MA
Cooper, DA
Nsanzimana, S
Saravanan, S
Charpentier, C
de Oliveira, T
Etiebet, MA
Garcia, F
Goedhals, D
Gomes, P
Günthard, HF
Hamers, RL
Hoffmann, CJ
Hunt, G
Jiamsakul, A
Kaleebu, P
Kanki, P
Kantor, R
Kerschberger, B
Marconi, VC
D'amour Ndahimana, J
Ndembi, N
Ngo-Giang-Huong, N
Rokx, C
Santoro, MM
Schapiro, JM
Schmidt, D
Seu, L
Sigaloff, KCE
Sirivichayakul, S
Skhosana, L
Sunpath, H
Tang, M
Yang, C
Carmona, S
Gupta, RK
Shafer, RW

March 2017

Tenofovir disoproxil fumarate (TDF) genotypic resistance defined by K65R/N and/or K70E/Q/G occurs in...

Prevalence of low and high abundance Transmitted Drug Resistance Mutations (TDRs) by antiretroviral drug class.

Max Lataillade (183356)
Jennifer Chiarella (183360)
Rong Yang (107028)
Steven Schnittman (364353)
Victoria Wirtz (364354)
Jonathan Uy (143781)
Daniel Seekins (183368)
Mark Krystal (364355)
Marco Mancini (364356)
Donnie McGrath (364357)
Birgitte Simen (183369)
Michael Egholm (180599)
Michael Kozal (183380)

February 2013

N(t)RTI(s)- nucleoside(tide) reverse transcriptase inhibitor; NNRTI – non-nucleoside rever...

Mutational Correlates of Virological Failure in Individuals Receiving a WHO-Recommended Tenofovir-Containing First-Line Regimen: An International Collaboration.

Rhee, Soo-Yon
Varghese, Vici
Holmes, Susan P
Van Zyl, Gert U
Steegen, Kim
Boyd, Mark A
Cooper, David A
Nsanzimana, Sabin
Saravanan, Shanmugam
Charpentier, Charlotte
de Oliveira, Tulio
Etiebet, Mary-Ann A
Garcia, Federico
Goedhals, Dominique
Gomes, Perpetua
Günthard, Huldrych F
Hamers, Raph L
Hoffmann, Christopher J
Hunt, Gillian
Jiamsakul, Awachana
Kaleebu, Pontiano
Kanki, Phyllis
Kantor, Rami
Kerschberger, Bernhard
Marconi, Vincent C
D'amour Ndahimana, Jean
Ndembi, Nicaise
Ngo-Giang-Huong, Nicole
Rokx, Casper
Santoro, Maria M
Schapiro, Jonathan M
Schmidt, Daniel
Seu, Lillian
Sigaloff, Kim C E
Sirivichayakul, Sunee
Skhosana, Lindiwe
Sunpath, Henry
Tang, Michele
Yang, Chunfu
Carmona, Sergio
Gupta, Ravindra K
Shafer, Robert W

March 2017

Tenofovir disoproxil fumarate (TDF) genotypic resistance defined by K65R/N and/or K70E/Q/G occurs in...

Transmitted Drug Resistance by ARV Class and Virologic Outcome.

Max Lataillade (183356)
Jennifer Chiarella (183360)
Rong Yang (107028)
Steven Schnittman (364353)
Victoria Wirtz (364354)
Jonathan Uy (143781)
Daniel Seekins (183368)
Mark Krystal (364355)
Marco Mancini (364356)
Donnie McGrath (364357)
Birgitte Simen (183369)
Michael Egholm (180599)
Michael Kozal (183380)

February 2013

Transmitted Drug Resistance by ARV Class and Virologic Outcome: Note: TDRs are not mutually exclu...

Predicted susceptibility to antiretroviral drugs of the 71 viruses carrying TDR mutations.

Gonzalo Yebra (294031)
Miguel de Mulder (294030)
María Jesús Pérez-Elías (192940)
José Antonio Pérez-Molina (189507)
Juan Carlos Galán (178955)
Jara Llenas-García (341262)
Santiago Moreno (90184)
África Holguín (3273111)

February 2013

Susceptibility was estimated according to the HIVdb Interpretation Algorithm (Stanford University...

Gupta, Ravindra
gregson, john
deenan, pillay
rawlings, datir
carlo, perno
Robert, Shafer
Anne, Derache

November 2019

Background: M184V/I cause high-level lamivudine (3TC) and emtricitabine (FTC) resistance, and increa...

Emergence of mutations.

Alexandra U. Scherrer (214775)
Jürg Böni (36157)
Sabine Yerly (82534)
Thomas Klimkait (178911)
Vincent Aubert (297526)
Hansjakob Furrer (93994)
Alexandra Calmy (36005)
Matthias Cavassini (146654)
Luigia Elzi (297529)
Pietro L. Vernazza (191358)
Enos Bernasconi (174329)
Bruno Ledergerber (93996)
Huldrych F. Günthard (173082)

February 2013

Accumulation of nucleoside reverse transcriptase inhibitor (NRTI) mutations after virological fai...

New resistance mutations to nucleoside reverse transcriptase inhibitors at codon 184 of HIV-1 reverse transcriptase (M184L and M184T)

Pouga L.
Santoro M. M.
Charpentier C.
Di Carlo D.
ROMEO, ILARIA
Artese A.
Alcaro S.
Antinori A.
Wirden M.
Perno C. F.
Ambrosio F. A.
Calvez V.
Descamps D.
Marcelin A. -G.
Ceccherini-Silberstein F.
Lambert-Niclot S.

January 2019

Mutations at HIV-1 reverse transcriptase (RT) codon 184 such as M184V confer resistance to two nucle...

Details of mutations found according to antiretroviral family and period of study.

Juan Ambrosioni (749142)
Omar Sued (132831)
David Nicolas (749143)
Marta Parera (749144)
María López-Diéguez (749145)
Anabel Romero (749146)
Fernando Agüero (276046)
María Ángeles Marcos (749147)
Christian Manzardo (341791)
Laura Zamora (232408)
Manuel Gómez-Carrillo (5652313)
José María Gatell (5653063)
Tomás Pumarola (178995)
José María Miró (749148)

June 2015

* Only mutations found in at least one case according to WHO list of TDR are listed.&...

Factors associated with the emergence of K65R in patients with HIV-1 infection treated with combination antiretroviral therapy containing tenofovir

von Wyl, Viktor
Yerly, Sabine
Böni, Jürg
Bürgisser, Philippe
Klimkait, Thomas
Battegay, Manuel
Bernasconi, Enos
Cavassini, Matthias
Furrer, Hansjakob
Hirschel, Bernard
Vernazza, Pietro L
Rickenbach, Martin
Ledergerber, Bruno
Günthard, Huldrych F

January 2008

BACKGROUND: The human immunodeficiency virus type 1 reverse-transcriptase mutation K65R is a single-...

Specific TDR patterns and levels for subjects with a M184V/I and/or K65R +/− TAMs.

Abstract

Extracted data

Specific TDR patterns and levels for subjects with a M184V/I and/or K65R +/− TAMs.

Abstract

Extracted data

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