Immunoblocking of integrins decreases the rate of cell motility.

<p>The initial scratch wound was carried out on uncoated culture dishes with confluent keratinocyte cultures (A), and on keratinocyte cultures treated with ASC-3 (B) and ASC-8 (C). Panels D–F illustrate repopulation of the wound surface after 24 hours by keratinocytes without the presence of antibodies (D), or in the presence of ASC-3 (E), or ASC-8 (F). Cells that migrated into the wound gap were calculated for each condition and the differences were expressed as a percentage of wound closure of NHK cell culture (G). Each bar represents the mean and the standard deviation of triplicate determinations in two separate experiments.