VEGF correlates with ALI onset during malaria infection.

<p>(<b>A</b>) Levels of VEGF protein in the sera of <i>P. berghei</i> ANKA-infected DBA mice with ALI and hyperparasitemia (HP), compared to non-infected mice (NI). Results are shown as mean concentration ± standard deviation (n = 6, 23 and 46 mouse sera per group, for NI, ALI and HP, respectively). (<b>B</b>) Expression of VEGF mRNA levels in the lung, spleen, liver and kidney of <i>P. berghei</i> ANKA-infected DBA mice with ALI and HP (n = 15 animals per group), when compared to non-infected mice. (<b>C</b>) Correlation between VEGF protein levels in the serum and mRNA expression of VEGF in the spleen of <i>P. berghei</i> ANKA-infected DBA mice with ALI. (<b>D</b>) Levels of VEGF protein in the sera of different strains of mice (C57BL/6, BALB/c and DBA) infected with different <i>Plasmodia</i> (<i>P. berghei</i> ANKA, <i>P. berghei</i> NK65 - PbNK, <i>P. yoelii yoelii</i> 17X – Py, and <i>P. chabaudi chabaudi</i> AS - Pc) (n = 10 animals per group). Results are shown as mean concentration ± standard deviation. (*<i>P</i><0.001).