Spleen is required for the onset of malaria-associated ALI.

<p>(<b>A</b>) Survival and (<b>B</b>) parasitemia of splenectomised and control <i>P. berghei</i> ANKA-infected DBA mice. (<b>C</b>) Levels of VEGF in the serum of non-infected (NI) DBA mice, <i>P. berghei</i> ANKA-infected DBA mice with ALI and splenectomised <i>P. berghei</i> ANKA-infected DBA mice were taken on the same day as control DBA infected mice developed ALI. Results are shown as mean concentration ± standard deviation. (*<i>P</i><0.01).