Comparison of ¹H MR spectra of untreated and minocycline treated macaques.

<p>(<b>A</b>) ¹H MR spectra from the white matter of a representative <u>untreated</u> macaque before infection and at 8 wpi. Spectra are scaled to the creatine (Cr) resonance. It can be seen from the spectra that NAA is decreased and Cho is increased at 8 wpi compared to baseline levels. (<b>B</b>) ¹H MR spectra from the white matter of a representative <u>minocycline treated</u> (persistently CD8-depleted) macaque before infection and at 8 wpi. Again, the spectra are scaled to the creatine resonance. It is clear that NAA/Cr has not decreased as much and also that Cho/Cr has not increased at 8 wpi.