Minocycline prevents NAA declines and Cr elevation.

<p>(<b>A</b>) NAA/Cr at the last MR scan is significantly different among the three cohorts in all four brain regions by ANOVA (PC p = 0.034, FC p = 0.009, BG p = 0.024 and WM p = 0.0065). NAA/Cr was found to be significantly higher in MN-treated, persistently CD8-depleted animals compared to animals not treated with MN in the FC (p = 0.024), BG (p = 0.033) and WM (p = 0.029) by Least Square means t-tests. NAA/Cr was also significantly higher in all brain regions in MN treated, short-term CD8-depleted animals when compared to the untreated animals (PC p = 0.0057, FC p = 0.0035, BG p = 0.01, and WM p = 0.002). No significant differences between the two MN-treated cohorts were identified. (<b>B</b>) NAA concentrations at the last MR scan are higher in MN-treated animals than in untreated animals. NAA levels are significantly different among the three cohorts in the BG by ANOVA (p = 0.0062). NAA was found to be significantly higher in MN-treated, long-term CD8-depleted animals (p = 0.015) and MN treated, short-term CD8-depleted animals (p = 0.0024). No significant differences between the two MN-treated cohorts were identified. (<b>C</b>) Cr concentrations at the last MR scan are lower in MN-treated animals and are significantly different between each of the three cohorts in the WM by ANOVA (p = 0.0042). Cr was found to be significantly lower in MN-treated, short-term CD8-depleted animals (p = 0.0014) compared to untreated animals. Here, differences between the two MN treated cohorts were also identified (p = 0.0092) showing higher Cr level in long-term CD8-depleted animals. <b><i>Horizontal bars within boxes represent mean values; height of each box corresponds to a factor of 1.5 times standard deviation.</i></b><i> </i><b><i>* indicates a significant difference (p≤0.05) between groups.</i></b>