<p>(<b>A</b>) IBA-1 expression in four representative sections from each of an uninfected, CD8-depleted animal (<b>control</b>), an untreated SIV-infected CD8-depleted animal (<b>1308</b>), a MN-treated persistently CD8-depleted animal (<b>7307</b>) and a MN-treated short-term CD8-depleted animal (7407). Visual inspection reveals less IBA-1 expression in the MN-treated animals. (<b>B</b>) Immunohistochemistry image analysis for IBA-1 in brain tissue sections of the frontal cortex. Data is given for four uninfected, CD8-depleted animals which served as controls (diamonds), four untreated SIV-infected CD8-depleted animals sacrificed at 8 wpi (solid squares) and four minocycline (MN)-treated (persistently CD8-depleted) animals. The mean for ea...
<p>(<b>A–H</b>) Brain sections taken from the cerebral cortex and probed by an antibody to Iba-1, in...
<p>As a marker for cerebral inflammation microglial cells were quantified by staining for Iba-1. (<b...
<p>Regression analyses were performed between the absolute numbers of each monocyte subset and the p...
<p>(<b>A</b>) NAA/Cr at the last MR scan is significantly different among the three cohorts in all f...
<p>NAA/Cr over the course of SIV infection in untreated animals (solid squares), minocycline (MN)-tr...
<p>A. Treated animals revealed lower plasma vRNA levels (~1 log) at endpoints when compared to untre...
<p>The release of TNF-α (<b>A</b>) and the percentage of proliferating microglial cells (determined ...
Minocycline is a tetracycline antibiotic that has been proposed as a potential conjunctive therapy f...
<p>Purified microglia were treated with vehicle (control) (A), Pb (50 µmol) (B), or Pb (50 µmol)+min...
<p>Representative (<b>A</b>) anti-ionized calcium binding adaptor molecule 1 (Iba1)-stained and (<b>...
<p>Immunohistochemistry was performed to compare CD68+ resident macrophages, newly infiltrating MAC3...
Microglia-brain macrophages are immune-competent cells of the CNS and respond to pathologic events. ...
<p>(A–E) Brain sections immunostained for Iba-1 at the indicated days after CCI. The red signals sho...
(a-b) Microglia activation was blocked in vivo using systemic treatment with minocycline. (a) Minocy...
We aim to characterize the kinetics of early and late microglial phenotypes after systemic inflammat...
<p>(<b>A–H</b>) Brain sections taken from the cerebral cortex and probed by an antibody to Iba-1, in...
<p>As a marker for cerebral inflammation microglial cells were quantified by staining for Iba-1. (<b...
<p>Regression analyses were performed between the absolute numbers of each monocyte subset and the p...
<p>(<b>A</b>) NAA/Cr at the last MR scan is significantly different among the three cohorts in all f...
<p>NAA/Cr over the course of SIV infection in untreated animals (solid squares), minocycline (MN)-tr...
<p>A. Treated animals revealed lower plasma vRNA levels (~1 log) at endpoints when compared to untre...
<p>The release of TNF-α (<b>A</b>) and the percentage of proliferating microglial cells (determined ...
Minocycline is a tetracycline antibiotic that has been proposed as a potential conjunctive therapy f...
<p>Purified microglia were treated with vehicle (control) (A), Pb (50 µmol) (B), or Pb (50 µmol)+min...
<p>Representative (<b>A</b>) anti-ionized calcium binding adaptor molecule 1 (Iba1)-stained and (<b>...
<p>Immunohistochemistry was performed to compare CD68+ resident macrophages, newly infiltrating MAC3...
Microglia-brain macrophages are immune-competent cells of the CNS and respond to pathologic events. ...
<p>(A–E) Brain sections immunostained for Iba-1 at the indicated days after CCI. The red signals sho...
(a-b) Microglia activation was blocked in vivo using systemic treatment with minocycline. (a) Minocy...
We aim to characterize the kinetics of early and late microglial phenotypes after systemic inflammat...
<p>(<b>A–H</b>) Brain sections taken from the cerebral cortex and probed by an antibody to Iba-1, in...
<p>As a marker for cerebral inflammation microglial cells were quantified by staining for Iba-1. (<b...
<p>Regression analyses were performed between the absolute numbers of each monocyte subset and the p...