3D structure of a Glo1 dimer according to [24].

<p>Colored residues show the position of Zn-ligands (blue) and GSH-ligands (magenta). The transparent blue cone placed in the upper monomer mimics the general position of a ligand in the barrel containing the active site. The flexible loop that closes upon ligation over the barrel is colored in gold, the cysteine residues in shades of red. We suggest that covalent binding of GSH to Cys¹³⁹ brings about a conformational change to the flexible loop that might subsequently close the barrel.