<p>*The nucleotide position corresponds to the position of viral DNA insertion at the top strand of the chromosome indicated. Symbols + and – within the parenthesis indicate the orientation of the viral transcription is the same and opposite, respectively, to the polarity of the top strand. GenBank accession numbers for the integration site sequences are GU816075 to GU816104.</p><p>†The left LTR of the provirus contains a 5-bp deletion that includes the conserved CA dinucleotide at the viral end.</p><p>ψThe target DNA contains a T to A transversion immediately adjacent to the left LTR (position 4).</p
Integration of retroviral cDNA into the host cell genome is a process central to the replication cyc...
<p>(A) Palindromic consensus sequence from sites of Rev-A integration <i>in vitro</i>. Observed freq...
<p>The putative target gene is shown, with the arrow indicating the transcriptional direction. Arrow...
Xenotropic murine leukemia virus (MLV)-related virus (XMRV) is a new human retrovirus associated wit...
<p>(A) DNA breaking and joining steps during integration. Viral and target DNA strands are represent...
<p>A schematic illustration of the unintegrated viral DNA is shown with the detailed structures of b...
<p>Base compositions of the 4-bp target site duplication (positions D1 to D4; demarcated by the thic...
a<p>Location of 5′ end of forward primer target site to 3′ end of reverse primer target site on XMRV...
<p>Shown are the genomic organizations of the parenteral XMRV provirus (XMRV-∆5U3), the provirus wit...
<p>A. Schematic representation of the MeV genome. The genome is depicted in the positive sense antig...
<p>(A) Schematic map of the 8185 nt XMRV genome. LTR regions (R, U5, U3) are indicated with boxes. P...
<p>Sequences extending from the alternative CUG start codon to the AUG start codon (underlined) of <...
<p>(A) Alignment of the leader/<i>gag</i> region, displaying the XMRV specific deletion. (B) Alignme...
Abstract Background The randomness of retroviral integration has been debated for many years. Recent...
The stable insertion of a copy of their genome into the host cell genome is an essential step of the...
Integration of retroviral cDNA into the host cell genome is a process central to the replication cyc...
<p>(A) Palindromic consensus sequence from sites of Rev-A integration <i>in vitro</i>. Observed freq...
<p>The putative target gene is shown, with the arrow indicating the transcriptional direction. Arrow...
Xenotropic murine leukemia virus (MLV)-related virus (XMRV) is a new human retrovirus associated wit...
<p>(A) DNA breaking and joining steps during integration. Viral and target DNA strands are represent...
<p>A schematic illustration of the unintegrated viral DNA is shown with the detailed structures of b...
<p>Base compositions of the 4-bp target site duplication (positions D1 to D4; demarcated by the thic...
a<p>Location of 5′ end of forward primer target site to 3′ end of reverse primer target site on XMRV...
<p>Shown are the genomic organizations of the parenteral XMRV provirus (XMRV-∆5U3), the provirus wit...
<p>A. Schematic representation of the MeV genome. The genome is depicted in the positive sense antig...
<p>(A) Schematic map of the 8185 nt XMRV genome. LTR regions (R, U5, U3) are indicated with boxes. P...
<p>Sequences extending from the alternative CUG start codon to the AUG start codon (underlined) of <...
<p>(A) Alignment of the leader/<i>gag</i> region, displaying the XMRV specific deletion. (B) Alignme...
Abstract Background The randomness of retroviral integration has been debated for many years. Recent...
The stable insertion of a copy of their genome into the host cell genome is an essential step of the...
Integration of retroviral cDNA into the host cell genome is a process central to the replication cyc...
<p>(A) Palindromic consensus sequence from sites of Rev-A integration <i>in vitro</i>. Observed freq...
<p>The putative target gene is shown, with the arrow indicating the transcriptional direction. Arrow...