<p>A. Growth in lungs of the isolate following intravenous infection. B. Growth in lungs following aerosol infection of mouse-passaged clinical isolate in comparison with regularly mouse-passaged H37Rv strain (JHU) in BALB/c mice. Errors are SD.</p
Additional file 2. H&E staining of lesions within lungs of C57BL/6 mice: 5 weeks (A) and 7 weeks (B)...
<p>Balb/c mice (n = 5) were infected with <i>M. tuberculosis</i> H37Rv by aerosol challenge and then...
<p>WT (black circles), TNF<sup>−/−</sup> (white diamonds) and Tm-TNF (white squares) mice were expos...
<p>(A) Early change in Mtb growth during the first 14 days of infection in C57BL/6 mice. (B) The ove...
<p><b>(A)</b> Groups of BALB/c mice were infected by aerosol route with either <i>M</i>. <i>tubercul...
<p>Mice were aerosol-infected with ~100 CFU of <i>M</i>. <i>tuberculosis</i> WT (squares), Δ<i>pstA2...
<p>(A) The indicated H37Rv-derived strains were normalized at a calculated optical density of 0.01 i...
It has been hypothesized that the virulence of lab-passaged Mycobacterium tuberculosis and recombina...
<p>(A) -1 log difference in lung CFU counts (N=5, P<0.001, ANOVA, 1 experiment of 3 similar); (B) – ...
<p>Low-dose aerosol infection was performed with the following <i>Mtb</i> strains: parental, KasB_T3...
<p>Low-dose aerosol infection of SCID mice (as in <b>B</b>) was performed with the following <i>Mtb<...
Five inbred strains of mice were examined for resistance to intravenous infection with 10^5 colony-...
<p>Mice were infected by aerosol with 100–200 bacilli per mouse, which was determined by lung CFU at...
<p>(A) Viable bacterial numbers in the lungs of wild-type (WT) and Mincle<sup>−/−</sup> mice (n≥4) w...
Clinical isolates of Mycobacterium tuberculosis demonstrate significant heterogeneity in virulence p...
Additional file 2. H&E staining of lesions within lungs of C57BL/6 mice: 5 weeks (A) and 7 weeks (B)...
<p>Balb/c mice (n = 5) were infected with <i>M. tuberculosis</i> H37Rv by aerosol challenge and then...
<p>WT (black circles), TNF<sup>−/−</sup> (white diamonds) and Tm-TNF (white squares) mice were expos...
<p>(A) Early change in Mtb growth during the first 14 days of infection in C57BL/6 mice. (B) The ove...
<p><b>(A)</b> Groups of BALB/c mice were infected by aerosol route with either <i>M</i>. <i>tubercul...
<p>Mice were aerosol-infected with ~100 CFU of <i>M</i>. <i>tuberculosis</i> WT (squares), Δ<i>pstA2...
<p>(A) The indicated H37Rv-derived strains were normalized at a calculated optical density of 0.01 i...
It has been hypothesized that the virulence of lab-passaged Mycobacterium tuberculosis and recombina...
<p>(A) -1 log difference in lung CFU counts (N=5, P<0.001, ANOVA, 1 experiment of 3 similar); (B) – ...
<p>Low-dose aerosol infection was performed with the following <i>Mtb</i> strains: parental, KasB_T3...
<p>Low-dose aerosol infection of SCID mice (as in <b>B</b>) was performed with the following <i>Mtb<...
Five inbred strains of mice were examined for resistance to intravenous infection with 10^5 colony-...
<p>Mice were infected by aerosol with 100–200 bacilli per mouse, which was determined by lung CFU at...
<p>(A) Viable bacterial numbers in the lungs of wild-type (WT) and Mincle<sup>−/−</sup> mice (n≥4) w...
Clinical isolates of Mycobacterium tuberculosis demonstrate significant heterogeneity in virulence p...
Additional file 2. H&E staining of lesions within lungs of C57BL/6 mice: 5 weeks (A) and 7 weeks (B)...
<p>Balb/c mice (n = 5) were infected with <i>M. tuberculosis</i> H37Rv by aerosol challenge and then...
<p>WT (black circles), TNF<sup>−/−</sup> (white diamonds) and Tm-TNF (white squares) mice were expos...