A convergent approach for the stereoselective synthesis of diverse spiroethers is described. The reaction involves stereoselective trapping of diazo-derived rhodium carbenoids with gold-activated alkynols for the installation of spiro cores. The reaction has proven general with a range of readily accessible homopropargylic alcohols and diazo carbonyls to provide functionalized spiroether cores of bioactive scaffolds such as spirobarbiturates, spirooxindoles, and pseurotin natural products
Stereoselective construction of spiro-fused tricyclic compounds from enynes having a tethered imine ...
Rh(III)-catalyzed [3 + 2] annulation of cyclic <i>N</i>-sulfonyl or <i>N</i>-acyl ketimines with ac...
Rh(III)-catalyzed [3 + 2] annulation of cyclic <i>N</i>-sulfonyl or <i>N</i>-acyl ketimines with ac...
A convergent approach for the stereoselective synthesis of diverse spiroethers is described. The rea...
A convergent approach for the stereoselective synthesis of diverse spiroethers is described. The rea...
International audienceThe synthetic utility of γ-alkylidenebutenolides is demonstrated as highly com...
International audienceThe synthetic utility of γ-alkylidenebutenolides is demonstrated as highly com...
International audienceThe synthetic utility of γ-alkylidenebutenolides is demonstrated as highly com...
International audienceThe synthetic utility of γ-alkylidenebutenolides is demonstrated as highly com...
Within the field of drug design, there is a great interest in the development of synthetic libraries...
The reaction of cyclic diazoamides with aryl aldehydes catalyzed by rhodium(II) acetate leads to int...
In the recent decade there has been a shift in drug development to favor planar, aromatic small mole...
A novel relay Rh (II)/cobaloxime (III) dual catalysis strategy has been developed for the stereosele...
The reaction of cyclic diazoamides with aryl aldehydes catalyzed by rhodium(II) acetate leads to int...
We have demonstrated a simple and an efficient method for the synthesis of spirocycles starting with...
Stereoselective construction of spiro-fused tricyclic compounds from enynes having a tethered imine ...
Rh(III)-catalyzed [3 + 2] annulation of cyclic <i>N</i>-sulfonyl or <i>N</i>-acyl ketimines with ac...
Rh(III)-catalyzed [3 + 2] annulation of cyclic <i>N</i>-sulfonyl or <i>N</i>-acyl ketimines with ac...
A convergent approach for the stereoselective synthesis of diverse spiroethers is described. The rea...
A convergent approach for the stereoselective synthesis of diverse spiroethers is described. The rea...
International audienceThe synthetic utility of γ-alkylidenebutenolides is demonstrated as highly com...
International audienceThe synthetic utility of γ-alkylidenebutenolides is demonstrated as highly com...
International audienceThe synthetic utility of γ-alkylidenebutenolides is demonstrated as highly com...
International audienceThe synthetic utility of γ-alkylidenebutenolides is demonstrated as highly com...
Within the field of drug design, there is a great interest in the development of synthetic libraries...
The reaction of cyclic diazoamides with aryl aldehydes catalyzed by rhodium(II) acetate leads to int...
In the recent decade there has been a shift in drug development to favor planar, aromatic small mole...
A novel relay Rh (II)/cobaloxime (III) dual catalysis strategy has been developed for the stereosele...
The reaction of cyclic diazoamides with aryl aldehydes catalyzed by rhodium(II) acetate leads to int...
We have demonstrated a simple and an efficient method for the synthesis of spirocycles starting with...
Stereoselective construction of spiro-fused tricyclic compounds from enynes having a tethered imine ...
Rh(III)-catalyzed [3 + 2] annulation of cyclic <i>N</i>-sulfonyl or <i>N</i>-acyl ketimines with ac...
Rh(III)-catalyzed [3 + 2] annulation of cyclic <i>N</i>-sulfonyl or <i>N</i>-acyl ketimines with ac...