The effect of central carbon metabolic gene deletions on cell growth and size.

<p>(A) Mutant phenotypes mapped onto central carbon metabolic pathways. Arrows are colored based on the phenotype as follows: black = normal growth and size; green = normal growth and small size (<10% smaller than WT); red = slow growth (>20% increase in doubling time) and small size; orange = normal growth and long cells (>10% larger than WT); blue = short and long cells; purple = highly variable size; and dotted lines = essential genes. Brown arrows correspond to deletions that obtained suppressor mutations rapidly and were not analyzed. Pathways are shaded as following: glycolysis/gluconeogenesis is blue, pentose phosphate pathway is green, Entner-Doudoroff is orange, acetate fermentation is red, and the TCA cycle is yellow. (B) Relationship between cell area and growth rate, as doublings per hour. Icons are colored as in panel (A).