Additional file 1: of Advantages of a multi-state approach in surgical research: how intermediate events and risk factor profile affect the prognosis of a patient with locally advanced rectal cancer

Appendix A. This file contains an introduction about multi-state models as well as the graphical representation of the model we used for the analysis of the data. Additionally, a flow-chart illustrates the procedure for the selection of the patients who could be included in the analysis together with a landmark analysis to assess the likelihood of informative missing. Appendix B Table 1b illustrates the localization of tumor recurrence and Table B2 shows the 5-year survival probability with 95%-CI at different timepoints after start of CTx both for Late discontinuation and for CTx = 12 m for the low risk patient. (PDF 120 kb