Brain levels of the β-site of APP cleaving enzyme (BACE-1) mRNA. Expression levels of mRNA were normalized to PGK1 and B2M mRNA expression. Animals belonged to three different study groups (wild-type(control), Thy-1 AβPPSL (control), and treatment group Thy-1 AβPPSL (MH84)). Data represent means ± SEM. N = 11 (six females, five males); one-way ANOVA with Tukey’s multiple comparison post test (**p < 0.01, against wild-type(control)). (TIFF 562 kb
Figure S8. REM reaches effective concentrations in brains of hAPP mice and improves their ability to...
Table S1. iTRAQ quantified human brain proteome of AD individuals and their age-matched control. The...
List of primary antibodies used in immunohistochemistry (IHC) and western blot (WB). (DOCX 28 kb
Western blot analysis of A brain-derived neurotrophic factor (BDNF), B Growth associated protein 43 ...
Representative NMR spectra of MH84 used for the current study. For analytical details please refer t...
Figure S5. Modulation of the JAK2-STAT3 pathway does not change expression of proteins involved in A...
AAV-PS1 and AAV-APP mice do not exhibit neuronal defects in terms of PSD-95, GLT-1 and tonic glutama...
APP is processed in sporadic AD cases. Human samples were obtained from late-onset AD cases (Braak 6...
NSE/APPsw transgenic mouse-derived brain slices treated with BDNF-depleted CM. (A) Western blot show...
Levels of transgenic human APP increase with age in APPswe/PS1ΔE9 mice. Representative immunoblot of...
The expression of Aβ-degrading enzymes in both in vivo and in vitro. (A) Transplantation of hNSCs (N...
Table S2. iTRAQ quantified human brain proteome of AD individuals and their age-matched control with...
Full Western blot of extracted samples from human superior frontal cortex obtained from subjects dia...
Figure S1. Analysis of APP levels in uninoculated AppNL-F mice. a Immunoblots of brain homogenates f...
Figure S3. HFD affects clearance of ISF Aβ. a, b The expression of APP, CTFα/β, BACE1 ADAM10 and α–t...
Figure S8. REM reaches effective concentrations in brains of hAPP mice and improves their ability to...
Table S1. iTRAQ quantified human brain proteome of AD individuals and their age-matched control. The...
List of primary antibodies used in immunohistochemistry (IHC) and western blot (WB). (DOCX 28 kb
Western blot analysis of A brain-derived neurotrophic factor (BDNF), B Growth associated protein 43 ...
Representative NMR spectra of MH84 used for the current study. For analytical details please refer t...
Figure S5. Modulation of the JAK2-STAT3 pathway does not change expression of proteins involved in A...
AAV-PS1 and AAV-APP mice do not exhibit neuronal defects in terms of PSD-95, GLT-1 and tonic glutama...
APP is processed in sporadic AD cases. Human samples were obtained from late-onset AD cases (Braak 6...
NSE/APPsw transgenic mouse-derived brain slices treated with BDNF-depleted CM. (A) Western blot show...
Levels of transgenic human APP increase with age in APPswe/PS1ΔE9 mice. Representative immunoblot of...
The expression of Aβ-degrading enzymes in both in vivo and in vitro. (A) Transplantation of hNSCs (N...
Table S2. iTRAQ quantified human brain proteome of AD individuals and their age-matched control with...
Full Western blot of extracted samples from human superior frontal cortex obtained from subjects dia...
Figure S1. Analysis of APP levels in uninoculated AppNL-F mice. a Immunoblots of brain homogenates f...
Figure S3. HFD affects clearance of ISF Aβ. a, b The expression of APP, CTFα/β, BACE1 ADAM10 and α–t...
Figure S8. REM reaches effective concentrations in brains of hAPP mice and improves their ability to...
Table S1. iTRAQ quantified human brain proteome of AD individuals and their age-matched control. The...
List of primary antibodies used in immunohistochemistry (IHC) and western blot (WB). (DOCX 28 kb