Western blot analysis of A brain-derived neurotrophic factor (BDNF), B Growth associated protein 43 (GAP43), and C synaptophysin in brain homogenate isolated from wild-type mice (control), Thy-1 AβPPSL (control), and MH-84-treated Thy-1 AβPPSL (MH84) mice. Tubulin (A, C) and GAPDH (B) were used as loading controls. Data represent means ± SEM. N = 11 (six females, five males); one-way ANOVA with Tukey’s multiple comparison post test (***p < 0.001, **p < 0.01, against wild-type(control); +p < 0.05 against Thy-1 AβPPSL (control)). (TIFF 12802 kb
Levels of α-syn immunoreactivity in individual oligodendroglial cells in the brains of MBP-α-syn tg ...
The expression of Aβ-degrading enzymes in both in vivo and in vitro. (A) Transplantation of hNSCs (N...
APN deficiency exacerbated astrogliosis in 5xFAD mice. (a) Representative images of GFAP immunoreact...
Brain levels of the β-site of APP cleaving enzyme (BACE-1) mRNA. Expression levels of mRNA were norm...
Representative NMR spectra of MH84 used for the current study. For analytical details please refer t...
Figure S3. HFD affects clearance of ISF Aβ. a, b The expression of APP, CTFα/β, BACE1 ADAM10 and α–t...
NSE/APPsw transgenic mouse-derived brain slices treated with BDNF-depleted CM. (A) Western blot show...
Figure S5. Modulation of the JAK2-STAT3 pathway does not change expression of proteins involved in A...
tau phosphorylation at the AT8 epitope was not significantly altered in L-methionine mice. A) Histol...
FigureS2. Unlike STAT3, STAT1 and Erk are not activated in APP astrocytes. Confocal images of staine...
Figure S3. The expressions of BiP and CHOP in the brains of the APP/PS1 transgenic mice and age- and...
APP is processed in sporadic AD cases. Human samples were obtained from late-onset AD cases (Braak 6...
Synaptophysin and MAP2 immunostaining in the hippocampus. (a)Enlarged view of synaptophysin staining...
Water consumption and body weight are not affected by a high-L-methionine diet. A) Water intake was ...
Figure S3. Validation of astrocyte sorting. Normalized expression of cell type specific genes. GFP+ ...
Levels of α-syn immunoreactivity in individual oligodendroglial cells in the brains of MBP-α-syn tg ...
The expression of Aβ-degrading enzymes in both in vivo and in vitro. (A) Transplantation of hNSCs (N...
APN deficiency exacerbated astrogliosis in 5xFAD mice. (a) Representative images of GFAP immunoreact...
Brain levels of the β-site of APP cleaving enzyme (BACE-1) mRNA. Expression levels of mRNA were norm...
Representative NMR spectra of MH84 used for the current study. For analytical details please refer t...
Figure S3. HFD affects clearance of ISF Aβ. a, b The expression of APP, CTFα/β, BACE1 ADAM10 and α–t...
NSE/APPsw transgenic mouse-derived brain slices treated with BDNF-depleted CM. (A) Western blot show...
Figure S5. Modulation of the JAK2-STAT3 pathway does not change expression of proteins involved in A...
tau phosphorylation at the AT8 epitope was not significantly altered in L-methionine mice. A) Histol...
FigureS2. Unlike STAT3, STAT1 and Erk are not activated in APP astrocytes. Confocal images of staine...
Figure S3. The expressions of BiP and CHOP in the brains of the APP/PS1 transgenic mice and age- and...
APP is processed in sporadic AD cases. Human samples were obtained from late-onset AD cases (Braak 6...
Synaptophysin and MAP2 immunostaining in the hippocampus. (a)Enlarged view of synaptophysin staining...
Water consumption and body weight are not affected by a high-L-methionine diet. A) Water intake was ...
Figure S3. Validation of astrocyte sorting. Normalized expression of cell type specific genes. GFP+ ...
Levels of α-syn immunoreactivity in individual oligodendroglial cells in the brains of MBP-α-syn tg ...
The expression of Aβ-degrading enzymes in both in vivo and in vitro. (A) Transplantation of hNSCs (N...
APN deficiency exacerbated astrogliosis in 5xFAD mice. (a) Representative images of GFAP immunoreact...