Testable predictions of specific protein-protein interaction sites.

<p>PKG kinase is shown in cartoon (A) and surface (B) representations, with the residues coloured according to their ID_scores. A cluster of high ID_scored residues that are solvent accessible and spatially proximal to each other is marked (A-B, <i>green circle</i>). This region that is formed at the junction of αE, αF and αH-helices is a putative candidate region involved in specific protein-protein interaction, potentially with WDR77. PKC kinase is shown in cartoon (C) and surface (D) representations, with the residues coloured according to their ID_scores. A cluster of high ID_scored residues that are solvent accessible and spatially proximal to each other is marked (C-D, <i>green circle</i>). This region that is formed at the junction of αG and αH-helices is a putative candidate region involved in specific protein-protein interaction, potentially with C1QBP. Models of (E) PKG-WDR77 and (F) PKC-C1QBP complexes docked at the ID_score predicted interfaces are presented.