<p>Scheme for the targeted <i>UL122/123</i> gene and its major splice variants for IE1 and IE2 with the position of the three designed gRNAs anti-HCMV and their corresponding sequences (Scissors: gRNA/Cas9 complex).</p
Hepatitis C virus (HCV) genotype 3a is considered a significant risk factor for the development of l...
© 2016 ElHefnawi et al. This is an open access article distributed under the terms of the Creative C...
SummaryHepatitis C virus (HCV) is a global health problem. Designing therapeutic agents that target ...
<p><b>a)</b> Targeting essential HCMV genes with CRISPR/Cas9 impairs HCMV replication. MRC5 cells tr...
Anti-HCMV treatments used in immunosuppressed patients reduce viral replication, but resistant viral...
<div><p>Anti-HCMV treatments used in immunosuppressed patients reduce viral replication, but resista...
Viruses within a given family often share common essential genes that are highly conserved due to th...
<p>(A) The proposed secondary structure of HCV IRES. The IRES region spanning nts 277–343 (shown in ...
<p>(<b>A</b>) Overview of the AdV Cas9 and gRNA constructs used in this study. CRISPR/Cas9 AdV const...
<p>(<b>A</b>) Schematic illustration of the CRISPR/Cas system. The guide RNA (gRNA) binds to the 20-...
<div><p>The hepatitis C virus (HCV) internal ribosome entry site (IRES) that directs cap-independent...
<p>The HCV proteins NS3, NS5A and CORE have the largest numbers of target genes in the optimal set o...
CRISPR/CAS9 gRNA sequence and Primers for mRNA detection, HBV DNA detection and site mutation.</p
AIM: To screen and investigate the effective gRNAs against hepatitis B virus (HBV) of genotypes A-D....
Persistence of hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) under current antivir...
Hepatitis C virus (HCV) genotype 3a is considered a significant risk factor for the development of l...
© 2016 ElHefnawi et al. This is an open access article distributed under the terms of the Creative C...
SummaryHepatitis C virus (HCV) is a global health problem. Designing therapeutic agents that target ...
<p><b>a)</b> Targeting essential HCMV genes with CRISPR/Cas9 impairs HCMV replication. MRC5 cells tr...
Anti-HCMV treatments used in immunosuppressed patients reduce viral replication, but resistant viral...
<div><p>Anti-HCMV treatments used in immunosuppressed patients reduce viral replication, but resista...
Viruses within a given family often share common essential genes that are highly conserved due to th...
<p>(A) The proposed secondary structure of HCV IRES. The IRES region spanning nts 277–343 (shown in ...
<p>(<b>A</b>) Overview of the AdV Cas9 and gRNA constructs used in this study. CRISPR/Cas9 AdV const...
<p>(<b>A</b>) Schematic illustration of the CRISPR/Cas system. The guide RNA (gRNA) binds to the 20-...
<div><p>The hepatitis C virus (HCV) internal ribosome entry site (IRES) that directs cap-independent...
<p>The HCV proteins NS3, NS5A and CORE have the largest numbers of target genes in the optimal set o...
CRISPR/CAS9 gRNA sequence and Primers for mRNA detection, HBV DNA detection and site mutation.</p
AIM: To screen and investigate the effective gRNAs against hepatitis B virus (HBV) of genotypes A-D....
Persistence of hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) under current antivir...
Hepatitis C virus (HCV) genotype 3a is considered a significant risk factor for the development of l...
© 2016 ElHefnawi et al. This is an open access article distributed under the terms of the Creative C...
SummaryHepatitis C virus (HCV) is a global health problem. Designing therapeutic agents that target ...