Theoretical model for PTEN Kinetics.
- Chun Liu (47227)
- Sanghamitra Deb (485341)
- Vinicius S. Ferreira (4856917)
- Eric Xu (151289)
- Tobias Baumgart (183997)
Publication date
February 2018
DOIAbstract
<p>YFP-PHGrp1 binds PI(3,4,5)P3 competitively with PTEN, which can only bind to and hydrolyze PI(3,4,5)P3 when Grp1 is not bound. We assume that free PI(3,4,5)P3 can be hydrolyzed via two paths, either by PI(4,5)P2-free PTEN (path 1, PTEN) or by PI(4,5)P2-bound PTEN (path 2, PTEN-PI(4,5)P2). When bound to PI(4,5)P2, PTEN can be allosterically activated and increases its hydrolysis activity towards PI(3,4,5)P3. Newly formed PI(4,5)P2 can also recruit more PTEN from solution to the membrane.</p
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