Loss of epithelial morphology.

<p>The inflammatory medium conditioned by macrophages induced a morphological shift in the epithelial colon cancer cell lines HT-29 and SW620 that was reminiscent of an epithelial-to-mesenchymal transition. Phase contrast microscopy images were obtained after treatment of colon cancer cell cultures for 2 days with the indicated conditioned media. <i>CON</i>, standard medium; <i>MONO-CM</i>, conditioned medium from non-activated monocytes; <i>MACRO-CM</i>, conditioned medium from differentiated macrophages.